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- W3119015366 abstract "Abstract The crystal structure of the light-gated anion channel Gt ACR1 reported in our previous research article ( Li et al., 2019 ) revealed a continuous tunnel traversing the protein from extracellular to intracellular pores. We proposed the tunnel as the conductance channel closed by three constrictions: C1 in the extracellular half, mid-membrane C2 containing the photoactive site, and C3 on the cytoplasmic side. Reported here, the crystal structure of bromide-bound Gt ACR1 reveals structural changes that relax the C1 and C3 constrictions, including a novel salt-bridge switch mechanism involving C1 and the photoactive site. These findings indicate that substrate binding induces a transition from an inactivated state to a pre-activated state in the dark that facilitates channel opening by reducing free energy in the tunnel constrictions. The results provide direct evidence that the tunnel is the closed form of the channel of Gt ACR1 and shed light on the light-gated channel activation mechanism. Impact Statement Substrate-induced structural changes in Gt ACR1 provide new insight into the chemical mechanism of natural light-gated anion conductance, and facilitate its optimization for photoinhibition of neuron firing in optogenetics." @default.
- W3119015366 created "2021-01-18" @default.
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- W3119015366 date "2021-01-02" @default.
- W3119015366 modified "2023-09-26" @default.
- W3119015366 title "The Crystal Structure of Bromide-Bound <i>Gt</i>ACR1 Reveals a Pre-Activated State in the Transmembrane Anion Tunnel" @default.
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- W3119015366 doi "https://doi.org/10.1101/2020.12.31.424927" @default.
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