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• W3119056190 endingPage "111841" @default.
• W3119056190 startingPage "111841" @default.
• W3119056190 abstract "Upconversion nanoparticles (UCNPs) are widely recognized exogenous contrast agents for bioimaging. Swept source optical coherence tomography (SSOCT) is a non-invasive imaging tool commissioned for cross-sectional imaging of the biological sample. We present polymerically modified UCNPs as a potential contrast agent for SSOCT. In this communication, functionalized NaYF4: Ho3+/Yb3+ UCNPs were synthesized for more bioavailability with a coating of two different polymers namely, polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP). Time-dependent diffusion dynamics of functionalized UCNPs were performed in-vivo with a mice model. Imaging was performed with both inactive and excited UCNPs. A separate optical system was developed with an amplitude modulated 980 nm laser source to excite UCNPs. UCNPs with PVP coating shows better results compared to others in terms of increase of scattering coefficients and contrast-to-noise ratio. The complete system is designed with purpose to enhance imaging contrast of tissue at molecular level with further possible extension as a theranostics system for tumor imaging during photodynamic therapy." @default.
• W3119056190 created "2021-01-18" @default.
• W3119056190 creator A5020359610 @default.
• W3119056190 creator A5050878973 @default.
• W3119056190 date "2021-02-01" @default.
• W3119056190 modified "2023-09-29" @default.
• W3119056190 title "Polymerically engineered upconversion nanoparticles (UCNPs) as contrast agent for functionally modified optical coherence tomography (OCT)" @default.
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• W3119056190 doi "https://doi.org/10.1016/j.msec.2020.111841" @default.
• W3119056190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33579479" @default.
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