Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119060209> ?p ?o ?g. }
- W3119060209 abstract "Abstract In the mid‐90s, hepatitis B virus (HBV)‐directed immune responses were for the first time investigated in detail and revealed suboptimal T‐cell responses in chronic HBV patients. Based on these studies, therapeutic vaccination exploiting the antigen presentation capacity of dendritic cells to prime and/or boost HBV‐specific T‐cell responses was considered highly promising. Now, 25 years later, it has not yet delivered this promise. In this review, we summarise what has been clinically tested in terms of antigen targets and vaccine forms, how the immunological and therapeutic effects of these vaccines were assessed and what major clinical and immunological findings were reported. We combine the lessons learned from these trials with the most recent insights on HBV antigen presentation, T‐cell responses, vaccine composition, antiviral and immune‐modulatory drugs and disease biomarkers to derive novel opportunities for the next generation of therapeutic vaccines designed to cure chronic HBV either alone or in combination therapy." @default.
- W3119060209 created "2021-01-18" @default.
- W3119060209 creator A5012066076 @default.
- W3119060209 creator A5018099461 @default.
- W3119060209 creator A5034377575 @default.
- W3119060209 creator A5034827806 @default.
- W3119060209 creator A5070232502 @default.
- W3119060209 date "2021-01-01" @default.
- W3119060209 modified "2023-10-03" @default.
- W3119060209 title "Designing the next‐generation therapeutic vaccines to cure chronic hepatitis B: focus on antigen presentation, vaccine properties and effect measures" @default.
- W3119060209 cites W1483823960 @default.
- W3119060209 cites W1500120385 @default.
- W3119060209 cites W1504083424 @default.
- W3119060209 cites W1519576779 @default.
- W3119060209 cites W1654854245 @default.
- W3119060209 cites W1688526230 @default.
- W3119060209 cites W1845254015 @default.
- W3119060209 cites W1910034918 @default.
- W3119060209 cites W1938515409 @default.
- W3119060209 cites W1979742563 @default.
- W3119060209 cites W1986771063 @default.
- W3119060209 cites W1987116953 @default.
- W3119060209 cites W1988855972 @default.
- W3119060209 cites W1998048927 @default.
- W3119060209 cites W2015760225 @default.
- W3119060209 cites W2020211914 @default.
- W3119060209 cites W2020860190 @default.
- W3119060209 cites W2021647336 @default.
- W3119060209 cites W2022538544 @default.
- W3119060209 cites W2029226756 @default.
- W3119060209 cites W2029325372 @default.
- W3119060209 cites W2033048068 @default.
- W3119060209 cites W2033588661 @default.
- W3119060209 cites W2036402301 @default.
- W3119060209 cites W2037387436 @default.
- W3119060209 cites W2043891615 @default.
- W3119060209 cites W2046941690 @default.
- W3119060209 cites W2051282088 @default.
- W3119060209 cites W2052217197 @default.
- W3119060209 cites W2053427888 @default.
- W3119060209 cites W2053900193 @default.
- W3119060209 cites W2054350989 @default.
- W3119060209 cites W2058988746 @default.
- W3119060209 cites W2059522845 @default.
- W3119060209 cites W2066303652 @default.
- W3119060209 cites W2070033188 @default.
- W3119060209 cites W2070100408 @default.
- W3119060209 cites W2075151840 @default.
- W3119060209 cites W2080731494 @default.
- W3119060209 cites W2083579463 @default.
- W3119060209 cites W2084152099 @default.
- W3119060209 cites W2085494369 @default.
- W3119060209 cites W2088139849 @default.
- W3119060209 cites W2091054183 @default.
- W3119060209 cites W2091703661 @default.
- W3119060209 cites W2096094255 @default.
- W3119060209 cites W2096866753 @default.
- W3119060209 cites W2098459535 @default.
- W3119060209 cites W2103452148 @default.
- W3119060209 cites W2107788106 @default.
- W3119060209 cites W2111629931 @default.
- W3119060209 cites W2116118057 @default.
- W3119060209 cites W2118434108 @default.
- W3119060209 cites W2127889847 @default.
- W3119060209 cites W2129651659 @default.
- W3119060209 cites W2138674743 @default.
- W3119060209 cites W2141609931 @default.
- W3119060209 cites W2152095262 @default.
- W3119060209 cites W2163001100 @default.
- W3119060209 cites W2171216965 @default.
- W3119060209 cites W2193557615 @default.
- W3119060209 cites W2267571233 @default.
- W3119060209 cites W2272228147 @default.
- W3119060209 cites W2337204897 @default.
- W3119060209 cites W2404295888 @default.
- W3119060209 cites W2408333651 @default.
- W3119060209 cites W2412344701 @default.
- W3119060209 cites W2512677348 @default.
- W3119060209 cites W2522072423 @default.
- W3119060209 cites W2549013240 @default.
- W3119060209 cites W2576582651 @default.
- W3119060209 cites W2605785536 @default.
- W3119060209 cites W2606276381 @default.
- W3119060209 cites W2612252787 @default.
- W3119060209 cites W2627084677 @default.
- W3119060209 cites W2724264513 @default.
- W3119060209 cites W2728365508 @default.
- W3119060209 cites W2738780043 @default.
- W3119060209 cites W2746448424 @default.
- W3119060209 cites W2757654367 @default.
- W3119060209 cites W2775465423 @default.
- W3119060209 cites W2781617771 @default.
- W3119060209 cites W2781766181 @default.
- W3119060209 cites W2782708334 @default.
- W3119060209 cites W2786264829 @default.
- W3119060209 cites W2796703505 @default.
- W3119060209 cites W2799465346 @default.
- W3119060209 cites W2800852021 @default.
- W3119060209 cites W2802499642 @default.
- W3119060209 cites W2806786489 @default.