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- W3119071725 abstract "Abstract Both Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) establish the persistent, life-long infection primarily at the latent status, and contribute to certain types of tumors, including B cell lymphomas, especially in immuno-compromised individuals, such as people living with HIV (PLWH). Lytic reactivation of these viruses can be employed to kill tumor cells harboring latently infected viral episomes, through the viral cytopathic effects and the subsequent antiviral immune responses. In this study, we identified that polo-like kinase 1 (PLK1) is induced by KSHV de novo infection as well as lytic switch from KSHV latency. We further demonstrated that PLK1 depletion or inhibition facilitates KSHV reactivation and promotes cell death of KSHV-reactivated lymphoma cells. Mechanistically, PLK1 regulates Myc that is critical to both maintenance of KSHV latency and support of cell survival, and preferentially affects the level of H3K27me3 inactive mark both globally and at certain loci of KSHV viral episomes. Lastly, we recognized that PLK1 inhibition synergizes with STAT3 inhibition to efficiently induce KSHV reactivation. Furthermore, we also confirmed that PLK1 depletion or inhibition yields the similar effect on EBV reactivation and cell death of EBV-reactivated lymphoma cells. Additionally, we noticed the PLK1 in B cells is elevated in the context of HIV infection and by HIV Nef protein, which would favor KSHV/EBV latency. Above all, our findings illustrated that PLK1 is a novel host target that can be inhibited to benefit the viral oncolysis to eliminate KSHV/EBV-infected lymphoma cells, particularly for PLWH." @default.
- W3119071725 created "2021-01-18" @default.
- W3119071725 creator A5005192531 @default.
- W3119071725 creator A5021843274 @default.
- W3119071725 creator A5022408570 @default.
- W3119071725 creator A5031062133 @default.
- W3119071725 creator A5051862250 @default.
- W3119071725 creator A5060287743 @default.
- W3119071725 creator A5079177940 @default.
- W3119071725 creator A5084593228 @default.
- W3119071725 creator A5091313888 @default.
- W3119071725 date "2020-10-08" @default.
- W3119071725 modified "2023-09-25" @default.
- W3119071725 title "Inhibition of polo-like kinase 1 (PLK1) facilitates reactivation of gamma-herpesviruses in B-cell lymphomas and their elimination" @default.
- W3119071725 cites W106947309 @default.
- W3119071725 cites W1774895213 @default.
- W3119071725 cites W1795403715 @default.
- W3119071725 cites W1861956965 @default.
- W3119071725 cites W1970339166 @default.
- W3119071725 cites W1970757470 @default.
- W3119071725 cites W1978130054 @default.
- W3119071725 cites W1986548436 @default.
- W3119071725 cites W1993778243 @default.
- W3119071725 cites W2008004643 @default.
- W3119071725 cites W2012666377 @default.
- W3119071725 cites W2014571799 @default.
- W3119071725 cites W2014744254 @default.
- W3119071725 cites W2015863723 @default.
- W3119071725 cites W2015878280 @default.
- W3119071725 cites W2019807707 @default.
- W3119071725 cites W2024329084 @default.
- W3119071725 cites W2025615902 @default.
- W3119071725 cites W2028483614 @default.
- W3119071725 cites W2032438721 @default.
- W3119071725 cites W2036238945 @default.
- W3119071725 cites W2037874673 @default.
- W3119071725 cites W2044484966 @default.
- W3119071725 cites W2045493291 @default.
- W3119071725 cites W2049069843 @default.
- W3119071725 cites W2052613054 @default.
- W3119071725 cites W2054101834 @default.
- W3119071725 cites W2054492080 @default.
- W3119071725 cites W2058703375 @default.
- W3119071725 cites W2061021700 @default.
- W3119071725 cites W2064863056 @default.
- W3119071725 cites W2067444184 @default.
- W3119071725 cites W2072047081 @default.
- W3119071725 cites W2072981794 @default.
- W3119071725 cites W2074871929 @default.
- W3119071725 cites W2075807666 @default.
- W3119071725 cites W2076750567 @default.
- W3119071725 cites W2081689148 @default.
- W3119071725 cites W2084086052 @default.
- W3119071725 cites W2092627144 @default.
- W3119071725 cites W2105021838 @default.
- W3119071725 cites W2107375011 @default.
- W3119071725 cites W2115268409 @default.
- W3119071725 cites W2122809296 @default.
- W3119071725 cites W2127019295 @default.
- W3119071725 cites W2134979684 @default.
- W3119071725 cites W2135058181 @default.
- W3119071725 cites W2138383542 @default.
- W3119071725 cites W2138408725 @default.
- W3119071725 cites W2143580680 @default.
- W3119071725 cites W2144903262 @default.
- W3119071725 cites W2147291569 @default.
- W3119071725 cites W2150862088 @default.
- W3119071725 cites W2151911795 @default.
- W3119071725 cites W2162702880 @default.
- W3119071725 cites W2171476379 @default.
- W3119071725 cites W2286498994 @default.
- W3119071725 cites W2299322249 @default.
- W3119071725 cites W2314480832 @default.
- W3119071725 cites W2341924879 @default.
- W3119071725 cites W2530831990 @default.
- W3119071725 cites W2537873018 @default.
- W3119071725 cites W2572831163 @default.
- W3119071725 cites W2608042896 @default.
- W3119071725 cites W2747080541 @default.
- W3119071725 cites W2767526093 @default.
- W3119071725 cites W2771193451 @default.
- W3119071725 cites W2784949616 @default.
- W3119071725 cites W2800473549 @default.
- W3119071725 cites W2801517459 @default.
- W3119071725 cites W2807147939 @default.
- W3119071725 cites W2807159917 @default.
- W3119071725 cites W2809643018 @default.
- W3119071725 cites W2888672154 @default.
- W3119071725 cites W2889670243 @default.
- W3119071725 cites W2891119826 @default.
- W3119071725 cites W2894397394 @default.
- W3119071725 cites W2896953490 @default.
- W3119071725 cites W2902609075 @default.
- W3119071725 cites W2902947740 @default.
- W3119071725 cites W2906052725 @default.
- W3119071725 cites W2909909804 @default.
- W3119071725 cites W2941930792 @default.
- W3119071725 cites W2973103181 @default.
- W3119071725 cites W2982116988 @default.
- W3119071725 cites W2991710795 @default.