FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119071804> ?p ?o ?g. }

• W3119071804 endingPage "563" @default.
• W3119071804 startingPage "554" @default.
• W3119071804 abstract "Ploidy or genome-wide chromosomal anomalies such as triploidy, diploid/triploid mixoploidy, chimerism, and genome-wide uniparental disomy are the cause of molar pregnancies, embryonic lethality, and developmental disorders. While triploidy and genome-wide uniparental disomy can be ascribed to fertilization or meiotic errors, the mechanisms causing mixoploidy and chimerism remain shrouded in mystery. Different models have been proposed, but all remain hypothetical and controversial, are deduced from the developmental persistent genomic constitutions present in the sample studied and lack direct evidence. New single-cell genomic methodologies, such as single-cell genome-wide haplotyping, provide an extended view of the constitution of normal and abnormal embryos and have further pinpointed the existence of mixoploidy in cleavage-stage embryos. Based on those recent findings, we suggest that genome-wide anomalies, which persist in fetuses and patients, can for a large majority be explained by a noncanonical first zygotic cleavage event, during which maternal and paternal genomes in a single zygote, segregate to different blastomeres. This process, termed heterogoneic division, provides an overarching theoretical basis for the different presentations of mixoploidy and chimerism." @default.
• W3119071804 created "2021-01-18" @default.
• W3119071804 creator A5041834500 @default.
• W3119071804 creator A5044268931 @default.
• W3119071804 creator A5077598674 @default.
• W3119071804 date "2021-02-01" @default.
• W3119071804 modified "2023-10-18" @default.
• W3119071804 title "Genome‐wide abnormalities in embryos: Origins and clinical consequences" @default.
• W3119071804 cites W1493909984 @default.
• W3119071804 cites W1967706827 @default.
• W3119071804 cites W1968418248 @default.
• W3119071804 cites W1972817655 @default.
• W3119071804 cites W1973578666 @default.
• W3119071804 cites W1974950904 @default.
• W3119071804 cites W1977193600 @default.
• W3119071804 cites W1982207438 @default.
• W3119071804 cites W1984368969 @default.
• W3119071804 cites W1987706229 @default.
• W3119071804 cites W1991469965 @default.
• W3119071804 cites W1994772528 @default.
• W3119071804 cites W1996430783 @default.
• W3119071804 cites W2002313501 @default.
• W3119071804 cites W2003538821 @default.
• W3119071804 cites W2016949369 @default.
• W3119071804 cites W2018468354 @default.
• W3119071804 cites W2023859871 @default.
• W3119071804 cites W2028785082 @default.
• W3119071804 cites W2032770898 @default.
• W3119071804 cites W2042860034 @default.
• W3119071804 cites W2044217484 @default.
• W3119071804 cites W2046362303 @default.
• W3119071804 cites W2049108913 @default.
• W3119071804 cites W2058843560 @default.
• W3119071804 cites W2061937072 @default.
• W3119071804 cites W2064166917 @default.
• W3119071804 cites W2067759553 @default.
• W3119071804 cites W2072957894 @default.
• W3119071804 cites W2073129338 @default.
• W3119071804 cites W2076717889 @default.
• W3119071804 cites W2078625748 @default.
• W3119071804 cites W2079371561 @default.
• W3119071804 cites W2082766417 @default.
• W3119071804 cites W2086682153 @default.
• W3119071804 cites W2088741884 @default.
• W3119071804 cites W2098131249 @default.
• W3119071804 cites W2099214085 @default.
• W3119071804 cites W2102187103 @default.
• W3119071804 cites W2102595033 @default.
• W3119071804 cites W2108989136 @default.
• W3119071804 cites W2115595133 @default.
• W3119071804 cites W2119671342 @default.
• W3119071804 cites W2120429387 @default.
• W3119071804 cites W2124534418 @default.
• W3119071804 cites W2124656409 @default.
• W3119071804 cites W2126058835 @default.
• W3119071804 cites W2130204626 @default.
• W3119071804 cites W2132144450 @default.
• W3119071804 cites W2132470016 @default.
• W3119071804 cites W2133381977 @default.
• W3119071804 cites W2136709801 @default.
• W3119071804 cites W2140582932 @default.
• W3119071804 cites W2142263549 @default.
• W3119071804 cites W2142766753 @default.
• W3119071804 cites W2144037014 @default.
• W3119071804 cites W2150896151 @default.
• W3119071804 cites W2155529634 @default.
• W3119071804 cites W2158041008 @default.
• W3119071804 cites W2160952541 @default.
• W3119071804 cites W2167696001 @default.
• W3119071804 cites W2170894935 @default.
• W3119071804 cites W2179284559 @default.
• W3119071804 cites W2287108501 @default.
• W3119071804 cites W2292436881 @default.
• W3119071804 cites W2338544936 @default.
• W3119071804 cites W2498651201 @default.
• W3119071804 cites W2520737352 @default.
• W3119071804 cites W2554798922 @default.
• W3119071804 cites W2562141785 @default.
• W3119071804 cites W2583816011 @default.
• W3119071804 cites W2593972640 @default.
• W3119071804 cites W2621037244 @default.
• W3119071804 cites W2760507087 @default.
• W3119071804 cites W2761032334 @default.
• W3119071804 cites W2761326476 @default.
• W3119071804 cites W2767736649 @default.
• W3119071804 cites W2775138882 @default.
• W3119071804 cites W2797682694 @default.
• W3119071804 cites W2800242374 @default.
• W3119071804 cites W2897178069 @default.
• W3119071804 cites W2899395470 @default.
• W3119071804 cites W2900375249 @default.
• W3119071804 cites W2905966310 @default.
• W3119071804 cites W2917939924 @default.
• W3119071804 cites W2919775779 @default.
• W3119071804 cites W2921752460 @default.
• W3119071804 cites W2929220631 @default.
• W3119071804 cites W2939264772 @default.
• W3119071804 cites W2946968670 @default.

• next