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- W3119073204 abstract "Maintenance of cellular proteostasis is vital for post-mitotic cells like neurons to sustain normal physiological function and homeostasis, defects in which are established hallmarks of several age-related conditions like AD, PD, HD, and ALS. The Spatio-temporal accumulation of aggregated proteins in the form of inclusion bodies/plaques is one of the major characteristics of many neurodegenerative diseases, including Huntington's disease (HD). Toxic accumulation of HUNTINGTIN (HTT) aggregates in neurons bring about the aberrant phenotypes of HD, including severe motor dysfunction, dementia, and cognitive impairment at the organismal level, in an age-dependent manner. In several cellular and animal models, aggrephagy induction has been shown to clear aggregate-prone proteins like HTT and ameliorate disease pathology by conferring neuroprotection. In this study, we used the mouse model of HD, R6/2, to understand the pathogenicity of mHTT aggregates, primarily focusing on autophagy dysfunction. We report that basal autophagy is not altered in R6/2 mice, whilst being functional at a steady-state level in neurons. Moreover, we tested the efficacy of a known autophagy modulator, Nilotinib (Tasigna™), presently in clinical trials for PD, and HD, in curbing mHTT aggregate growth and their potential clearance, which was ineffective in both inducing autophagy and rescuing the pathological phenotypes in R6/2 mice." @default.
- W3119073204 created "2021-01-18" @default.
- W3119073204 creator A5024417766 @default.
- W3119073204 creator A5031040780 @default.
- W3119073204 creator A5036917805 @default.
- W3119073204 creator A5057366280 @default.
- W3119073204 creator A5066734409 @default.
- W3119073204 creator A5071401788 @default.
- W3119073204 date "2021-01-08" @default.
- W3119073204 modified "2023-10-03" @default.
- W3119073204 title "Spatiotemporal analysis of soluble aggregates and autophagy markers in the R6/2 mouse model" @default.
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