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- W3119084804 abstract "Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine with antioxidant, chronobiotic and anti-inflammatory properties; reduced levels of this hormone are associated with higher risk of cancer. Several beneficial effects of melatonin have been described in a broad number of tumors, including liver cancers. In this work we systematically reviewed the publications of the last 15 years that assessed the underlying mechanisms of melatonin activities against liver cancers, and its role as coadjuvant in the treatment of these tumors. Literature research was performed employing PubMed, Scopus and Web of Science (WOS) databases and, after screening, 51 articles were included. Results from the selected studies denoted the useful actions of melatonin in preventing carcinogenesis and as a promising treatment option for the primary liver tumors hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), either alone or in combination with other compounds. Different processes were modulated by the indole, such as inhibition of oxidative stress, proliferation, angiogenesis and invasion, promotion of immune system response, cell cycle arrest and apoptosis, as well as recovery of circadian rhythms and autophagy modulation. Taken together, the present systematic review highlights the evidence that document the potential role of melatonin in improving the landscape of liver tumor treatment." @default.
- W3119084804 created "2021-01-18" @default.
- W3119084804 creator A5031653173 @default.
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- W3119084804 date "2021-01-12" @default.
- W3119084804 modified "2023-10-18" @default.
- W3119084804 title "Melatonin as an Antitumor Agent against Liver Cancer: An Updated Systematic Review" @default.
- W3119084804 cites W1583010521 @default.
- W3119084804 cites W1583940256 @default.
- W3119084804 cites W1956142364 @default.
- W3119084804 cites W1966604963 @default.
- W3119084804 cites W1989239469 @default.
- W3119084804 cites W2008244839 @default.
- W3119084804 cites W2009579436 @default.
- W3119084804 cites W2013838468 @default.
- W3119084804 cites W2024226207 @default.
- W3119084804 cites W2032425910 @default.
- W3119084804 cites W2047740187 @default.
- W3119084804 cites W2048517423 @default.
- W3119084804 cites W2053243600 @default.
- W3119084804 cites W2053462924 @default.
- W3119084804 cites W2064932230 @default.
- W3119084804 cites W2070955337 @default.
- W3119084804 cites W2078823089 @default.
- W3119084804 cites W2083834339 @default.
- W3119084804 cites W2084482878 @default.
- W3119084804 cites W2088988390 @default.
- W3119084804 cites W2093060455 @default.
- W3119084804 cites W2093557429 @default.
- W3119084804 cites W2095407436 @default.
- W3119084804 cites W2096498477 @default.
- W3119084804 cites W2101025849 @default.
- W3119084804 cites W2123373938 @default.
- W3119084804 cites W2133054989 @default.
- W3119084804 cites W2137278952 @default.
- W3119084804 cites W2138918717 @default.
- W3119084804 cites W2142490215 @default.
- W3119084804 cites W2143187760 @default.
- W3119084804 cites W2159437534 @default.
- W3119084804 cites W2205425710 @default.
- W3119084804 cites W2407351686 @default.
- W3119084804 cites W2412783057 @default.
- W3119084804 cites W2504816780 @default.
- W3119084804 cites W2529856835 @default.
- W3119084804 cites W2586682700 @default.
- W3119084804 cites W2587302795 @default.
- W3119084804 cites W2597174991 @default.
- W3119084804 cites W2606778500 @default.
- W3119084804 cites W2606820045 @default.
- W3119084804 cites W2618876418 @default.
- W3119084804 cites W2736693285 @default.
- W3119084804 cites W2738694063 @default.
- W3119084804 cites W2753496952 @default.
- W3119084804 cites W2785545673 @default.
- W3119084804 cites W2789881042 @default.
- W3119084804 cites W2793972506 @default.
- W3119084804 cites W2800668750 @default.
- W3119084804 cites W2804432927 @default.
- W3119084804 cites W2805766913 @default.
- W3119084804 cites W2889646458 @default.
- W3119084804 cites W2890554786 @default.
- W3119084804 cites W2891198237 @default.
- W3119084804 cites W2892757136 @default.
- W3119084804 cites W2897214576 @default.
- W3119084804 cites W2924855259 @default.
- W3119084804 cites W2930873894 @default.
- W3119084804 cites W2963099938 @default.
- W3119084804 cites W2967835500 @default.
- W3119084804 cites W2976156847 @default.
- W3119084804 cites W2989326381 @default.
- W3119084804 cites W2989629572 @default.
- W3119084804 cites W2991029237 @default.
- W3119084804 cites W2992186857 @default.
- W3119084804 cites W3011670387 @default.
- W3119084804 cites W3022387787 @default.
- W3119084804 cites W3029690703 @default.
- W3119084804 cites W3036137214 @default.
- W3119084804 cites W3039266078 @default.
- W3119084804 cites W3042759466 @default.
- W3119084804 cites W3045887819 @default.
- W3119084804 cites W3082943564 @default.
- W3119084804 cites W4249224946 @default.
- W3119084804 cites W4294215472 @default.
- W3119084804 doi "https://doi.org/10.3390/antiox10010103" @default.
- W3119084804 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7828223" @default.
- W3119084804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33445767" @default.
- W3119084804 hasPublicationYear "2021" @default.
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