FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119085705> ?p ?o ?g. }

• W3119085705 endingPage "198" @default.
• W3119085705 startingPage "198" @default.
• W3119085705 abstract "Our aim was to determine the prevalence, prognostic and predictive role of germline pathogenic/likely pathogenic variants (P/LPVs) in cancer predisposing genes in patients with pancreatic ductal adenocarcinoma (PDAC). Germline testing of 62 cancer susceptibility genes was performed on unselected patients diagnosed from 02/2003 to 01/2020 with PDAC, treated at Hellenic Cooperative Oncology Group (HeCOG)-affiliated Centers. The main endpoints were prevalence of P/LPVs and overall survival (OS). P/LPVs in PDAC-associated and homologous recombination repair (HRR) genes were identified in 22 (4.0%) and 42 (7.7%) of 549 patients, respectively. P/LPVs were identified in 16 genes, including ATM (11, 2.0%) and BRCA2 (6, 1.1%), while 19 patients (3.5%) were heterozygotes for MUTYH P/LPVs and 9 (1.6%) carried the low-risk allele, CHEK2 p.(Ile157Thr). Patients carrying P/LPVs had improved OS compared to non-carriers (22.6 vs. 13.9 months, p = 0.006). In multivariate analysis, there was a trend for improved OS in P/LPV carriers (p = 0.063). The interaction term between platinum exposure and mutational status of HRR genes was not significant (p-value = 0.35). A significant proportion of patients with PDAC carries clinically relevant germline P/LPVs, irrespectively of age, family history or disease stage. The predictive role of these P/LPVs has yet to be defined. ClinicalTrials.gov Identifier: NCT03982446." @default.
• W3119085705 created "2021-01-18" @default.
• W3119085705 creator A5002813173 @default.
• W3119085705 creator A5005087419 @default.
• W3119085705 creator A5005489735 @default.
• W3119085705 creator A5011077706 @default.
• W3119085705 creator A5012112204 @default.
• W3119085705 creator A5012258280 @default.
• W3119085705 creator A5012832857 @default.
• W3119085705 creator A5014605303 @default.
• W3119085705 creator A5018787724 @default.
• W3119085705 creator A5019758131 @default.
• W3119085705 creator A5021315519 @default.
• W3119085705 creator A5026269698 @default.
• W3119085705 creator A5030109945 @default.
• W3119085705 creator A5034182778 @default.
• W3119085705 creator A5034507679 @default.
• W3119085705 creator A5039349296 @default.
• W3119085705 creator A5041575636 @default.
• W3119085705 creator A5047656028 @default.
• W3119085705 creator A5048322584 @default.
• W3119085705 creator A5049900739 @default.
• W3119085705 creator A5053006338 @default.
• W3119085705 creator A5056643910 @default.
• W3119085705 creator A5060334897 @default.
• W3119085705 creator A5063134810 @default.
• W3119085705 creator A5063212748 @default.
• W3119085705 creator A5064636994 @default.
• W3119085705 creator A5067080871 @default.
• W3119085705 creator A5070188844 @default.
• W3119085705 creator A5074458672 @default.
• W3119085705 creator A5081271665 @default.
• W3119085705 creator A5086594420 @default.
• W3119085705 creator A5087834972 @default.
• W3119085705 creator A5087963010 @default.
• W3119085705 creator A5088046602 @default.
• W3119085705 creator A5089796322 @default.
• W3119085705 date "2021-01-08" @default.
• W3119085705 modified "2023-10-16" @default.
• W3119085705 title "Clinical Significance of Germline Cancer Predisposing Variants in Unselected Patients with Pancreatic Adenocarcinoma" @default.
• W3119085705 cites W1838826168 @default.
• W3119085705 cites W1844119416 @default.
• W3119085705 cites W1980125751 @default.
• W3119085705 cites W2035801850 @default.
• W3119085705 cites W2051978340 @default.
• W3119085705 cites W2092259915 @default.
• W3119085705 cites W2119180969 @default.
• W3119085705 cites W2146542392 @default.
• W3119085705 cites W2147918436 @default.
• W3119085705 cites W2154866190 @default.
• W3119085705 cites W2161479848 @default.
• W3119085705 cites W2726331924 @default.
• W3119085705 cites W2738571634 @default.
• W3119085705 cites W2741937391 @default.
• W3119085705 cites W2791631640 @default.
• W3119085705 cites W2792327545 @default.
• W3119085705 cites W2805031648 @default.
• W3119085705 cites W2809494794 @default.
• W3119085705 cites W2810883871 @default.
• W3119085705 cites W2883600652 @default.
• W3119085705 cites W2886054665 @default.
• W3119085705 cites W2911550830 @default.
• W3119085705 cites W2913041225 @default.
• W3119085705 cites W2947826965 @default.
• W3119085705 cites W2984359187 @default.
• W3119085705 cites W2989421973 @default.
• W3119085705 cites W2989955432 @default.
• W3119085705 cites W2998609748 @default.
• W3119085705 cites W3001713806 @default.
• W3119085705 cites W3008479902 @default.
• W3119085705 cites W3015069968 @default.
• W3119085705 cites W3030206881 @default.
• W3119085705 cites W3091797030 @default.
• W3119085705 doi "https://doi.org/10.3390/cancers13020198" @default.
• W3119085705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7827324" @default.
• W3119085705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33429865" @default.
• W3119085705 hasPublicationYear "2021" @default.
• W3119085705 type Work @default.
• W3119085705 sameAs 3119085705 @default.
• W3119085705 citedByCount "8" @default.
• W3119085705 countsByYear W31190857052021 @default.
• W3119085705 countsByYear W31190857052022 @default.
• W3119085705 countsByYear W31190857052023 @default.
• W3119085705 crossrefType "journal-article" @default.
• W3119085705 hasAuthorship W3119085705A5002813173 @default.
• W3119085705 hasAuthorship W3119085705A5005087419 @default.
• W3119085705 hasAuthorship W3119085705A5005489735 @default.
• W3119085705 hasAuthorship W3119085705A5011077706 @default.
• W3119085705 hasAuthorship W3119085705A5012112204 @default.
• W3119085705 hasAuthorship W3119085705A5012258280 @default.
• W3119085705 hasAuthorship W3119085705A5012832857 @default.
• W3119085705 hasAuthorship W3119085705A5014605303 @default.
• W3119085705 hasAuthorship W3119085705A5018787724 @default.
• W3119085705 hasAuthorship W3119085705A5019758131 @default.
• W3119085705 hasAuthorship W3119085705A5021315519 @default.
• W3119085705 hasAuthorship W3119085705A5026269698 @default.
• W3119085705 hasAuthorship W3119085705A5030109945 @default.
• W3119085705 hasAuthorship W3119085705A5034182778 @default.

• next