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- W3119097597 endingPage "320" @default.
- W3119097597 startingPage "308" @default.
- W3119097597 abstract "Bile acids (BAs) are classically known to play a vital role in the metabolism of lipids and in absorption. It is now well established that BAs act as signaling molecules, activating different receptors (such as farnesoid X receptor, vitamin D receptor, Takeda G-protein-coupled receptor 5, sphingosine-1-phosphate, muscarinic receptors, and big potassium channels) and participating in the regulation of energy homeostasis and lipid and glucose metabolism. In addition, increased BAs can impair cardiovascular function in liver cirrhosis. Approximately 50% of patients with cirrhosis develop cirrhotic cardiomyopathy. Exposure to high concentrations of hydrophobic BAs has been shown to be related to adverse effects with respect to vascular tension, endothelial function, arrhythmias, coronary atherosclerotic heart disease, and heart failure. The BAs in the serum BA pool have relevant through their hydrophobicity, and the lipophilic BAs are more harmful to the heart. Interestingly, ursodeoxycholic acid is a hydrophilic BA, and it is used as a therapeutic drug to reverse and protect the harmful cardiac effects caused by hydrophobic elevated BAs. In order to elucidate the mechanism of BAs and cardiovascular function, abundant experiments have been conducted in vitro and in vivo. The aim of this review was to explore the mechanism of BAs in the cardiovascular system." @default.
- W3119097597 created "2021-01-18" @default.
- W3119097597 creator A5032841164 @default.
- W3119097597 creator A5047892458 @default.
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- W3119097597 creator A5077448119 @default.
- W3119097597 creator A5077832069 @default.
- W3119097597 creator A5083411115 @default.
- W3119097597 date "2021-01-16" @default.
- W3119097597 modified "2023-10-16" @default.
- W3119097597 title "Overview of bile acid signaling in the cardiovascular system" @default.
- W3119097597 cites W1521283732 @default.
- W3119097597 cites W1786148865 @default.
- W3119097597 cites W1860026848 @default.
- W3119097597 cites W1964390622 @default.
- W3119097597 cites W1965452329 @default.
- W3119097597 cites W1970363592 @default.
- W3119097597 cites W1975141304 @default.
- W3119097597 cites W1977493036 @default.
- W3119097597 cites W1981194757 @default.
- W3119097597 cites W1982604124 @default.
- W3119097597 cites W1982918806 @default.
- W3119097597 cites W1985056901 @default.
- W3119097597 cites W1990450603 @default.
- W3119097597 cites W1992166522 @default.
- W3119097597 cites W1999074834 @default.
- W3119097597 cites W1999774383 @default.
- W3119097597 cites W2005786213 @default.
- W3119097597 cites W2006012100 @default.
- W3119097597 cites W2012065014 @default.
- W3119097597 cites W2013209482 @default.
- W3119097597 cites W2014512153 @default.
- W3119097597 cites W2016514413 @default.
- W3119097597 cites W2017362076 @default.
- W3119097597 cites W2023826147 @default.
- W3119097597 cites W2024685706 @default.
- W3119097597 cites W2035013442 @default.
- W3119097597 cites W2036004493 @default.
- W3119097597 cites W2036236019 @default.
- W3119097597 cites W2038177382 @default.
- W3119097597 cites W2038720743 @default.
- W3119097597 cites W2042764818 @default.
- W3119097597 cites W2042793529 @default.
- W3119097597 cites W2043431677 @default.
- W3119097597 cites W2045920651 @default.
- W3119097597 cites W2051767032 @default.
- W3119097597 cites W2052638070 @default.
- W3119097597 cites W2055724589 @default.
- W3119097597 cites W2057849582 @default.
- W3119097597 cites W2058785685 @default.
- W3119097597 cites W2061457959 @default.
- W3119097597 cites W2062622512 @default.
- W3119097597 cites W2062808581 @default.
- W3119097597 cites W2062817574 @default.
- W3119097597 cites W2072953898 @default.
- W3119097597 cites W2074545460 @default.
- W3119097597 cites W2077943638 @default.
- W3119097597 cites W2079742453 @default.
- W3119097597 cites W2080757873 @default.
- W3119097597 cites W2081028309 @default.
- W3119097597 cites W2082671505 @default.
- W3119097597 cites W2083008324 @default.
- W3119097597 cites W2083328033 @default.
- W3119097597 cites W2085901253 @default.
- W3119097597 cites W2092636887 @default.
- W3119097597 cites W2093686699 @default.
- W3119097597 cites W2096418655 @default.
- W3119097597 cites W2106515170 @default.
- W3119097597 cites W2109649607 @default.
- W3119097597 cites W2110290183 @default.
- W3119097597 cites W2110797810 @default.
- W3119097597 cites W2114306284 @default.
- W3119097597 cites W2115151725 @default.
- W3119097597 cites W2118406741 @default.
- W3119097597 cites W2119867228 @default.
- W3119097597 cites W2119884716 @default.
- W3119097597 cites W2121846817 @default.
- W3119097597 cites W2122241300 @default.
- W3119097597 cites W2124260053 @default.
- W3119097597 cites W2131655174 @default.
- W3119097597 cites W2132951309 @default.
- W3119097597 cites W2133070067 @default.
- W3119097597 cites W2134153423 @default.
- W3119097597 cites W2138658411 @default.
- W3119097597 cites W2142789398 @default.
- W3119097597 cites W2148873853 @default.
- W3119097597 cites W2153468913 @default.
- W3119097597 cites W2160835284 @default.
- W3119097597 cites W2162017875 @default.
- W3119097597 cites W2164631652 @default.
- W3119097597 cites W2168112142 @default.
- W3119097597 cites W2169078659 @default.
- W3119097597 cites W2171398834 @default.
- W3119097597 cites W2194800798 @default.
- W3119097597 cites W2263583031 @default.