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- W3119098710 abstract "Objective To observe the effect of moxibustion at acupoint-open on-time （Linggui Bafa） on immune function and nuclear factor-κB (NF-κB) signaling pathway in aging rats, so as to reveal its underlying mechanism of anti-agingt. Methods Forty SD rats were randomly divided into control, model, Linggui Bafa and Shenque (CV8) groups (n=10 in each group). Aging model was established by intraperitoneal injection of D-galactose (300 mg/kg) for 42 days. Moxibustion was applied at acupoint-open on-time or CV8 once daily for 28 days. The serum levels of TNF-α, IgG, IgA and IgM were detected by ELISA. The spleen index of rats was calculated. The expression of NF-κB p65 and NF-κB inhibitor protein (IκB) α mRNA of spleen tissues was detected by real-time PCR. Results Compared with the control group, the expression level of serum TNF-α, the mRNA expression levels of NF-κB p65 and IκBα in the model group was significantly increased (P 0.05). Conclusion Moxibustion at both acupoint-open on-time and CV8 can enhance the immune function of aging rats, which may be related to its effects in inhibiting NF-κB signaling pathway." @default.
- W3119098710 created "2021-01-18" @default.
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- W3119098710 date "2020-12-25" @default.
- W3119098710 modified "2023-09-26" @default.
- W3119098710 title "[Effect of moxibustion at acupoint-open on-time on immune function and nuclear factor-κB signaling pathway in aging rats]." @default.
- W3119098710 doi "https://doi.org/10.13702/j.1000-0607.200079" @default.
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