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- W3119116683 abstract "Introduction This paper describes the protocol for an ongoing project funded by the Royal Society, the Resilience After Individual Stress Exposure (RAISE) study; which aims to examine the factors and mechanisms that facilitate resilient functioning after childhood adversity (CA). Methods and analysis We aim to recruit up to 200 participants. We will use dimension reduction techniques (principal component analysis) on standard-normally transformed individual parameters of mental health, social functioning and CA to calculate a composite measure of adaptive (ie, ‘resilient’) psychosocial functioning. To examine the neuroimmune responses to stress and their relationship with the brain and social environment, we will use a well validated functional MRI task; the Montreal imaging stress task and venepuncture. We will run group or dimensional comparisons in multiple levels of biological and psychological outcomes, as well as mediation and moderation analyses to study how key biological systems (ie, the hypothalamic–pituitary–adrenal axis and the immune system) interrelate and interact with brain function and social influences in order to facilitate resilient functioning after CA. We hypothesise that resilient functioning will be facilitated by reduced morning cortisol and cytokine levels before and after the stressor and improved neural responses to such stress, as well as increased gray matter volume in the hippocampus and prefrontal cortex, enhanced inhibitory control and emotion regulation, and more friendship and family support. Ethics and dissemination This study has been reviewed and given favourable opinion by the National Research Ethics Service, NRES Committee East of England-Cambridge Central and external reviewers from the Royal Society (RGFR1180064 and RGFEA180029). The results of the RAISE study will be disseminated through (1) publications in scientific peer reviewed journals, (2) presentations on relevant scientific conferences and meetings, (3) publications and presentations for the general public and (4) through social media." @default.
- W3119116683 created "2021-01-18" @default.
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- W3119116683 date "2021-01-01" @default.
- W3119116683 modified "2023-10-14" @default.
- W3119116683 title "RAISE study protocol: a cross-sectional, multilevel, neurobiological study of resilience after individual stress exposure" @default.
- W3119116683 cites W1173674213 @default.
- W3119116683 cites W1524959298 @default.
- W3119116683 cites W1569173481 @default.
- W3119116683 cites W1584609572 @default.
- W3119116683 cites W1732425222 @default.
- W3119116683 cites W1826521770 @default.
- W3119116683 cites W1867115258 @default.
- W3119116683 cites W1890675559 @default.
- W3119116683 cites W1968712199 @default.
- W3119116683 cites W1979068472 @default.
- W3119116683 cites W1981459575 @default.
- W3119116683 cites W1981813430 @default.
- W3119116683 cites W1989012023 @default.
- W3119116683 cites W1995051494 @default.
- W3119116683 cites W1996299251 @default.
- W3119116683 cites W2001910860 @default.
- W3119116683 cites W2006656085 @default.
- W3119116683 cites W2007073022 @default.
- W3119116683 cites W2009942475 @default.
- W3119116683 cites W2011136641 @default.
- W3119116683 cites W2011142659 @default.
- W3119116683 cites W2011498445 @default.
- W3119116683 cites W2019779929 @default.
- W3119116683 cites W2022389253 @default.
- W3119116683 cites W2027105284 @default.
- W3119116683 cites W2030301826 @default.
- W3119116683 cites W2030407676 @default.
- W3119116683 cites W2036970657 @default.
- W3119116683 cites W2038184188 @default.
- W3119116683 cites W2039211719 @default.
- W3119116683 cites W2046396841 @default.
- W3119116683 cites W2049511110 @default.
- W3119116683 cites W2052124375 @default.
- W3119116683 cites W2053774762 @default.
- W3119116683 cites W2057017838 @default.
- W3119116683 cites W2062221375 @default.
- W3119116683 cites W2063102819 @default.
- W3119116683 cites W2067422206 @default.
- W3119116683 cites W2071609095 @default.
- W3119116683 cites W2072484905 @default.
- W3119116683 cites W2087160026 @default.
- W3119116683 cites W2088355439 @default.
- W3119116683 cites W2093956584 @default.
- W3119116683 cites W2094422818 @default.
- W3119116683 cites W2098952248 @default.
- W3119116683 cites W2102748276 @default.
- W3119116683 cites W2104282538 @default.
- W3119116683 cites W2104386846 @default.
- W3119116683 cites W2109186297 @default.
- W3119116683 cites W2114429947 @default.
- W3119116683 cites W2114879270 @default.
- W3119116683 cites W2117309811 @default.
- W3119116683 cites W2117760232 @default.
- W3119116683 cites W2123552131 @default.
- W3119116683 cites W2128152843 @default.
- W3119116683 cites W2128414222 @default.
- W3119116683 cites W2128564163 @default.
- W3119116683 cites W2130316988 @default.
- W3119116683 cites W2131285266 @default.
- W3119116683 cites W2135652748 @default.
- W3119116683 cites W2136022845 @default.
- W3119116683 cites W2149032634 @default.
- W3119116683 cites W2150693380 @default.
- W3119116683 cites W2154741607 @default.
- W3119116683 cites W2158598050 @default.
- W3119116683 cites W2158946645 @default.
- W3119116683 cites W2170711467 @default.
- W3119116683 cites W2171212397 @default.
- W3119116683 cites W2257349255 @default.
- W3119116683 cites W2271144139 @default.
- W3119116683 cites W2306468413 @default.
- W3119116683 cites W2336814115 @default.
- W3119116683 cites W2402570933 @default.
- W3119116683 cites W2419403191 @default.
- W3119116683 cites W2607480187 @default.
- W3119116683 cites W2763081536 @default.
- W3119116683 cites W2766915375 @default.
- W3119116683 cites W2770741845 @default.
- W3119116683 cites W2784423340 @default.
- W3119116683 cites W2801211613 @default.
- W3119116683 cites W2801316185 @default.
- W3119116683 cites W2804961480 @default.
- W3119116683 cites W2900657545 @default.
- W3119116683 cites W2907030468 @default.
- W3119116683 cites W2913243945 @default.