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- W3119128230 abstract "Iron has a key role in the activation of the autophagic pathway in rats with intracerebral hemorrhage (ICH), and hepcidin has the ability to reduce brain iron in ICH-rats. We therefore hypothesized that hepcidin might be able to inhibit autophagy by reducing iron in an ICH brain. Here, we investigated the effects of Ad-hepcidin and/or hepcidin peptide on autophagic activities in ICH models in vitro and in vivo. We demonstrated that ad-hepcidin and hepcidin peptide both inhibited hemin-induced increase in LC3-II/LC3-I conversion ratio and reversed the reduction in p62 content in cortical neurons in vitro. We also showed that ad-hepcidin inhibited ICH-induced increase in LC3-II/LC3-I conversion ratio and reversed ICH-induced reduction in p62 content in the brain cortex of rats in vivo. Based on these findings plus previous data on the effects of ad-hepcidin and/or hepcidin peptide on iron contents in ICH models, we suggested that hepcidin-induced inhibition of autophagy might be mediated via reducing iron in hemin-treated neurons in vitro and ICH-rat brain in vivo." @default.
- W3119128230 created "2021-01-18" @default.
- W3119128230 creator A5014542458 @default.
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- W3119128230 date "2021-03-01" @default.
- W3119128230 modified "2023-09-27" @default.
- W3119128230 title "Hepcidin inhibits autophagy in intracerebral hemorrhage models in vitro and in vivo." @default.
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- W3119128230 doi "https://doi.org/10.1016/j.mcn.2021.103589" @default.
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