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• W3119137899 endingPage "111854" @default.
• W3119137899 startingPage "111854" @default.
• W3119137899 abstract "Thymidine kinase expressing human adipose mesenchymal stem cells (TK-hAMSCs) in combination with ganciclovir (GCV) are an effective platform for antitumor bystander therapy in mice models. However, this strategy requires multiple TK-hAMSCs administrations and a substantial number of cells. Therefore, for clinical translation, it is necessary to find a biocompatible scaffold providing TK-hAMSCs retention in the implantation site against their rapid wash-out. We have developed a microtissue (MT) composed by TKhAMSCs and a scaffold made of polylactic acid microparticles and cell-derived extracellular matrix deposited by hAMSCs. The efficacy of these MTs as vehicles for TK-hAMSCs/GCV bystander therapy was evaluated in a rodent model of human prostate cancer. Subcutaneously implanted MTs were integrated in the surrounding tissue, allowing neovascularization and maintenance of TK-hAMSCs viability. Furthermore, MTs implanted beside tumors allowed TK-hAMSCs migration towards tumor cells and, after GCV administration, inhibited tumor growth. These results indicate that TK-hAMSCs-MTs are promising cell reservoirs for clinical use of therapeutic MSCs in bystander therapies." @default.
• W3119137899 created "2021-01-18" @default.
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• W3119137899 creator A5070654684 @default.
• W3119137899 date "2021-02-01" @default.
• W3119137899 modified "2023-10-18" @default.
• W3119137899 title "Engineered microtissues for the bystander therapy against cancer" @default.
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• W3119137899 doi "https://doi.org/10.1016/j.msec.2020.111854" @default.
• W3119137899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33579487" @default.
• W3119137899 hasPublicationYear "2021" @default.
• W3119137899 type Work @default.
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