FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119150740> ?p ?o ?g. }

• W3119150740 endingPage "108456" @default.
• W3119150740 startingPage "108456" @default.
• W3119150740 abstract "Recent evidence suggests that kappa opioid receptors (KOR) in limbic brain regions such as the amygdala contribute to pain conditions, but underlying mechanisms remain to be determined. The amygdala is an important player in averse-affective aspects of pain and pain modulation. The central nucleus (CeA) serves output functions through projection neurons that include corticotropin releasing factor (CRF) expressing neurons. The CeA is also rich in KOR. Here we tested the novel hypothesis that KOR activation in the CeA generates pain-like behaviors through a mechanism that involves inhibition of synaptic inhibition (disinhibition) of CRF neurons. Intra-CeA administration of a KOR agonist (U-69,593) increased vocalizations of naïve rats to noxious stimuli, and induced anxiety-like behaviors in the open field test (OFT) and avoidance in the conditioned place preference test, without affecting mechanosensory thresholds. Optogenetic silencing of CeA-CRF neurons blocked the facilitatory effects of systemically applied U-69,593 in naïve rats. Patch-clamp recordings of CRF neurons in rat brain slices found that U-69,593 decreased feedforward inhibitory transmission evoked by optogenetic stimulation of parabrachial afferents, but had no effect on monosynaptic excitatory transmission. U-69,593 decreased frequency, but not amplitude, of inhibitory synaptic currents, suggesting a presynaptic action. Multiphoton imaging of CeA-CRF neurons in rat brain slices showed that U-69,593 increased calcium signals evoked by electrical stimulation of presumed parabrachial input. This study shows for the first time that KOR activation increases activity of amygdala CRF neurons through synaptic disinhibition, resulting in averse-affective pain-like behaviors. Blocking KOR receptors may therefore represent a novel therapeutic strategy." @default.
• W3119150740 created "2021-01-18" @default.
• W3119150740 creator A5047172665 @default.
• W3119150740 creator A5054742181 @default.
• W3119150740 creator A5070563043 @default.
• W3119150740 creator A5070703610 @default.
• W3119150740 creator A5071744431 @default.
• W3119150740 creator A5072229323 @default.
• W3119150740 creator A5074514647 @default.
• W3119150740 creator A5083434028 @default.
• W3119150740 creator A5086674481 @default.
• W3119150740 date "2021-03-01" @default.
• W3119150740 modified "2023-10-17" @default.
• W3119150740 title "Kappa opioid receptor activation in the amygdala disinhibits CRF neurons to generate pain-like behaviors" @default.
• W3119150740 cites W1650998670 @default.
• W3119150740 cites W1745700293 @default.
• W3119150740 cites W1761628643 @default.
• W3119150740 cites W1862521538 @default.
• W3119150740 cites W1945735147 @default.
• W3119150740 cites W1966182087 @default.
• W3119150740 cites W1968651154 @default.
• W3119150740 cites W1976402500 @default.
• W3119150740 cites W1979031324 @default.
• W3119150740 cites W1980400989 @default.
• W3119150740 cites W1981183620 @default.
• W3119150740 cites W1982326881 @default.
• W3119150740 cites W1983754627 @default.
• W3119150740 cites W1999561809 @default.
• W3119150740 cites W2001470706 @default.
• W3119150740 cites W2002542669 @default.
• W3119150740 cites W2003474183 @default.
• W3119150740 cites W2014359029 @default.
• W3119150740 cites W2022248485 @default.
• W3119150740 cites W2022367291 @default.
• W3119150740 cites W2023615480 @default.
• W3119150740 cites W2025653825 @default.
• W3119150740 cites W2027523863 @default.
• W3119150740 cites W2029142963 @default.
• W3119150740 cites W2041074598 @default.
• W3119150740 cites W2045742399 @default.
• W3119150740 cites W2046389491 @default.
• W3119150740 cites W2046915594 @default.
• W3119150740 cites W2050750919 @default.
• W3119150740 cites W2060053691 @default.
• W3119150740 cites W2062106032 @default.
• W3119150740 cites W2065436616 @default.
• W3119150740 cites W2074108050 @default.
• W3119150740 cites W2074990816 @default.
• W3119150740 cites W2078671315 @default.
• W3119150740 cites W2098925781 @default.
• W3119150740 cites W2114270674 @default.
• W3119150740 cites W2117693696 @default.
• W3119150740 cites W2129143684 @default.
• W3119150740 cites W2129239485 @default.
• W3119150740 cites W2137636180 @default.
• W3119150740 cites W2140257707 @default.
• W3119150740 cites W2144933081 @default.
• W3119150740 cites W2145062794 @default.
• W3119150740 cites W2156314253 @default.
• W3119150740 cites W2159259673 @default.
• W3119150740 cites W2171046955 @default.
• W3119150740 cites W2232850269 @default.
• W3119150740 cites W2278798383 @default.
• W3119150740 cites W2301614195 @default.
• W3119150740 cites W2336840495 @default.
• W3119150740 cites W2570245225 @default.
• W3119150740 cites W2604616342 @default.
• W3119150740 cites W2749326925 @default.
• W3119150740 cites W2796871073 @default.
• W3119150740 cites W2801864057 @default.
• W3119150740 cites W2808113489 @default.
• W3119150740 cites W2890681211 @default.
• W3119150740 cites W2891830541 @default.
• W3119150740 cites W2902566357 @default.
• W3119150740 cites W2902832378 @default.
• W3119150740 cites W2921968057 @default.
• W3119150740 cites W2922078783 @default.
• W3119150740 cites W2922184287 @default.
• W3119150740 cites W2962118359 @default.
• W3119150740 cites W2978286181 @default.
• W3119150740 cites W2979822571 @default.
• W3119150740 cites W2979848972 @default.
• W3119150740 cites W2985174824 @default.
• W3119150740 cites W3014161817 @default.
• W3119150740 cites W3046137259 @default.
• W3119150740 cites W4212917819 @default.
• W3119150740 doi "https://doi.org/10.1016/j.neuropharm.2021.108456" @default.
• W3119150740 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7887082" @default.
• W3119150740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33444637" @default.
• W3119150740 hasPublicationYear "2021" @default.
• W3119150740 type Work @default.
• W3119150740 sameAs 3119150740 @default.
• W3119150740 citedByCount "18" @default.
• W3119150740 countsByYear W31191507402021 @default.
• W3119150740 countsByYear W31191507402022 @default.
• W3119150740 countsByYear W31191507402023 @default.
• W3119150740 crossrefType "journal-article" @default.
• W3119150740 hasAuthorship W3119150740A5047172665 @default.

• next