Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119165967> ?p ?o ?g. }
- W3119165967 endingPage "421" @default.
- W3119165967 startingPage "409" @default.
- W3119165967 abstract "Abstract Fungal infections are one of the most prevalent diseases in the world and there is a lack of new antifungal drug development for these diseases. We conducted a systematic review of the literature regarding the in vitro antifungal activity of the organoselenium compounds ebselen (Eb) and diphenyl diselenide [(PhSe)2]. A systematic review was carried out based on the search for articles with data concerning Minimal Inhibitory Concentration (MIC) values, indexed in international databases and published until August 2020. A total of 2337 articles were found, and, according to the inclusion and exclusion criteria used, 22 articles were included in the study. Inhibitory activity against 96% (200/208) and 95% (312/328) of the pathogenic fungi tested was described for Eb and [(PhSe)2], respectively. Including in these 536 fungal isolates tested, organoselenium activity was highlighted against Candida spp., Cryptococcus ssp., Trichosporon spp., Aspergillus spp., Fusarium spp., Pythium spp., and Sporothrix spp., with MIC values lower than 64 μg/mL. In conclusion, Eb and [(PhSe)2] have a broad spectrum of in vitro inhibitory antifungal activity. These data added with other pharmacological properties of these organoselenium compounds suggest that both compounds are potential future antifungal drugs. Whether MICs toward the upper end of the ranges described here are compatible with efficacious therapy, and whether they may achieve such end as a result of the favorable non-antimicrobial effects of selenium on the host, requires more in vivo testing." @default.
- W3119165967 created "2021-01-18" @default.
- W3119165967 creator A5005676299 @default.
- W3119165967 creator A5021143803 @default.
- W3119165967 creator A5052017399 @default.
- W3119165967 creator A5065249087 @default.
- W3119165967 creator A5078723579 @default.
- W3119165967 creator A5085519842 @default.
- W3119165967 creator A5090574713 @default.
- W3119165967 date "2021-01-09" @default.
- W3119165967 modified "2023-10-04" @default.
- W3119165967 title "Ebselen and diphenyl diselenide against fungal pathogens: A systematic review" @default.
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