Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119172395> ?p ?o ?g. }
- W3119172395 endingPage "153" @default.
- W3119172395 startingPage "144" @default.
- W3119172395 abstract "Vernal keratoconjunctivitis (VKC) is a severe and recurrent allergic conjunctivitis, the mechanism of which is not well understood. In this study, we investigated the role of oncostatin M (OSM) in the pathogenesis of VKC, with a focus on tissue remodeling. Clinical and experimental. The OSM concentrations in tear fluid samples obtained from VKC patients and healthy controls were measured using ELISA, and the expression of OSM mRNA and protein in giant papillae resected from VKC patients was investigated using RT-PCR and immunohistochemistry, respectively. In cultured human conjunctival epithelial cells (HconEpiCs), expression of OSM receptor β (OSMRβ) was detected using immunocytochemical and FACS analyses. Finally, we investigated whether recombinant OSM activated STAT1 and STAT3 to induce the expression of various genes related to tissue remodeling in HconEpiCs, by using Western blot analysis, microarray analysis, and RT-PCR. The OSM concentration was higher in the tear fluid of VKC patients than in that of the healthy controls, and strong expression of OSM mRNA was found in the giant papillae. We also detected T cells expressing OSM in the giant papillae. In addition, HconEpiCs showed surface expression of OSMRβ. Recombinant human OSM strongly activated both STAT1 and STAT3 in HconEpiCs and induced various tissue remodeling-related genes, including MMP-1, MMP-3, IL-24, IL-20, serpinB3, S100A7, tenascin C, and SOCS3. Our results suggest that OSM is one of the key molecules involved in remodeling of giant papillae in VKC." @default.
- W3119172395 created "2021-01-18" @default.
- W3119172395 creator A5004900386 @default.
- W3119172395 creator A5020018980 @default.
- W3119172395 creator A5032094157 @default.
- W3119172395 creator A5038710773 @default.
- W3119172395 creator A5060234898 @default.
- W3119172395 creator A5062680884 @default.
- W3119172395 creator A5072469686 @default.
- W3119172395 creator A5073358204 @default.
- W3119172395 creator A5087193515 @default.
- W3119172395 date "2021-01-01" @default.
- W3119172395 modified "2023-10-03" @default.
- W3119172395 title "Role of oncostatin M in the pathogenesis of vernal keratoconjunctivitis: focus on tissue remodeling" @default.
- W3119172395 cites W1562744510 @default.
- W3119172395 cites W1616393669 @default.
- W3119172395 cites W1924115225 @default.
- W3119172395 cites W1963588374 @default.
- W3119172395 cites W1975224746 @default.
- W3119172395 cites W1978142607 @default.
- W3119172395 cites W1986111930 @default.
- W3119172395 cites W1988193415 @default.
- W3119172395 cites W2005415233 @default.
- W3119172395 cites W2006530491 @default.
- W3119172395 cites W2018073132 @default.
- W3119172395 cites W2040229433 @default.
- W3119172395 cites W2040883232 @default.
- W3119172395 cites W2055352910 @default.
- W3119172395 cites W2061977596 @default.
- W3119172395 cites W2062583997 @default.
- W3119172395 cites W2063326250 @default.
- W3119172395 cites W2073404233 @default.
- W3119172395 cites W2076705364 @default.
- W3119172395 cites W2083576842 @default.
- W3119172395 cites W2092663747 @default.
- W3119172395 cites W2099573376 @default.
- W3119172395 cites W2117564935 @default.
- W3119172395 cites W2119238566 @default.
- W3119172395 cites W2159014577 @default.
- W3119172395 cites W2163690739 @default.
- W3119172395 cites W2313415636 @default.
- W3119172395 cites W2346075988 @default.
- W3119172395 cites W2411779324 @default.
- W3119172395 cites W2563444955 @default.
- W3119172395 cites W2626275980 @default.
- W3119172395 cites W2730402578 @default.
- W3119172395 cites W2893631054 @default.
- W3119172395 cites W2922504778 @default.
- W3119172395 cites W2955537388 @default.
- W3119172395 cites W2964538931 @default.
- W3119172395 cites W3027954628 @default.
- W3119172395 cites W4248469839 @default.
- W3119172395 cites W88943984 @default.
- W3119172395 doi "https://doi.org/10.1007/s10384-020-00791-8" @default.
- W3119172395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33403505" @default.
- W3119172395 hasPublicationYear "2021" @default.
- W3119172395 type Work @default.
- W3119172395 sameAs 3119172395 @default.
- W3119172395 citedByCount "7" @default.
- W3119172395 countsByYear W31191723952021 @default.
- W3119172395 countsByYear W31191723952022 @default.
- W3119172395 countsByYear W31191723952023 @default.
- W3119172395 crossrefType "journal-article" @default.
- W3119172395 hasAuthorship W3119172395A5004900386 @default.
- W3119172395 hasAuthorship W3119172395A5020018980 @default.
- W3119172395 hasAuthorship W3119172395A5032094157 @default.
- W3119172395 hasAuthorship W3119172395A5038710773 @default.
- W3119172395 hasAuthorship W3119172395A5060234898 @default.
- W3119172395 hasAuthorship W3119172395A5062680884 @default.
- W3119172395 hasAuthorship W3119172395A5072469686 @default.
- W3119172395 hasAuthorship W3119172395A5073358204 @default.
- W3119172395 hasAuthorship W3119172395A5087193515 @default.
- W3119172395 hasConcept C104317684 @default.
- W3119172395 hasConcept C11988809 @default.
- W3119172395 hasConcept C142724271 @default.
- W3119172395 hasConcept C203014093 @default.
- W3119172395 hasConcept C204232928 @default.
- W3119172395 hasConcept C2776415932 @default.
- W3119172395 hasConcept C2776469317 @default.
- W3119172395 hasConcept C2776581183 @default.
- W3119172395 hasConcept C2776914184 @default.
- W3119172395 hasConcept C2777667943 @default.
- W3119172395 hasConcept C2778690821 @default.
- W3119172395 hasConcept C2780942790 @default.
- W3119172395 hasConcept C55493867 @default.
- W3119172395 hasConcept C71924100 @default.
- W3119172395 hasConcept C86803240 @default.
- W3119172395 hasConceptScore W3119172395C104317684 @default.
- W3119172395 hasConceptScore W3119172395C11988809 @default.
- W3119172395 hasConceptScore W3119172395C142724271 @default.
- W3119172395 hasConceptScore W3119172395C203014093 @default.
- W3119172395 hasConceptScore W3119172395C204232928 @default.
- W3119172395 hasConceptScore W3119172395C2776415932 @default.
- W3119172395 hasConceptScore W3119172395C2776469317 @default.
- W3119172395 hasConceptScore W3119172395C2776581183 @default.
- W3119172395 hasConceptScore W3119172395C2776914184 @default.
- W3119172395 hasConceptScore W3119172395C2777667943 @default.
- W3119172395 hasConceptScore W3119172395C2778690821 @default.