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• W3119184430 abstract "Abstract Background Usutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis and meningoencephalitis). Similar to other flaviviruses, such as West Nile virus, USUV is capable of reaching the central nervous system. However, the neuropathogenesis of USUV is still poorly understood, and the virulence of the specific USUV lineages is currently unknown. One of the major complexities of the study of USUV pathogenesis is the presence of a great diversity of lineages circulating at the same time and in the same location. Methods The aim of this work was to determine the neurovirulence of isolates from the six main lineages circulating in Europe using mouse model and several neuronal cell lines (neurons, microglia, pericytes, brain endothelial cells, astrocytes, and in vitro Blood-Brain Barrier model). Results Our results indicate that all strains are neurotropic but have different virulence profiles. The Europe 2 strain, previously described as being involved in several clinical cases, induced the shortest survival time and highest mortality in vivo and appeared to be more virulent and persistent in microglial, astrocytes, and brain endothelial cells, while also inducing an atypical cytopathic effect. Moreover, an amino acid substitution (D3425E) was specifically identified in the RNA-dependent RNA polymerase domain of the NS5 protein of this lineage. Conclusions Altogether, these data show a broad neurotropism for USUV in the central nervous system with lineage-dependent virulence. Our results will help to better understand the biological and epidemiological diversity of USUV infection." @default.
• W3119184430 created "2021-01-18" @default.
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• W3119184430 date "2021-01-06" @default.
• W3119184430 modified "2023-10-15" @default.
• W3119184430 title "Differential neurovirulence of Usutu virus lineages in mice and neuronal cells" @default.
• W3119184430 cites W1557590746 @default.
• W3119184430 cites W1623942788 @default.
• W3119184430 cites W1932202918 @default.
• W3119184430 cites W1968754528 @default.
• W3119184430 cites W1970760661 @default.
• W3119184430 cites W1972163933 @default.
• W3119184430 cites W1980261991 @default.
• W3119184430 cites W1987297468 @default.
• W3119184430 cites W1987596905 @default.
• W3119184430 cites W1987935605 @default.
• W3119184430 cites W1988479476 @default.
• W3119184430 cites W1989069389 @default.
• W3119184430 cites W1995815488 @default.
• W3119184430 cites W2001290997 @default.
• W3119184430 cites W2010082930 @default.
• W3119184430 cites W2010802032 @default.
• W3119184430 cites W2011361113 @default.
• W3119184430 cites W2020735656 @default.
• W3119184430 cites W2022717804 @default.
• W3119184430 cites W2022981588 @default.
• W3119184430 cites W2027504445 @default.
• W3119184430 cites W2033828724 @default.
• W3119184430 cites W2038929331 @default.
• W3119184430 cites W2050431757 @default.
• W3119184430 cites W2052578334 @default.
• W3119184430 cites W2054110459 @default.
• W3119184430 cites W2054676351 @default.
• W3119184430 cites W2060801924 @default.
• W3119184430 cites W2065470651 @default.
• W3119184430 cites W2067911201 @default.
• W3119184430 cites W2071107608 @default.
• W3119184430 cites W2072764395 @default.
• W3119184430 cites W2077909994 @default.
• W3119184430 cites W2078811876 @default.
• W3119184430 cites W2079350274 @default.
• W3119184430 cites W2087736278 @default.
• W3119184430 cites W2097459101 @default.
• W3119184430 cites W2111706086 @default.
• W3119184430 cites W2118122091 @default.
• W3119184430 cites W2119337283 @default.
• W3119184430 cites W2133709345 @default.
• W3119184430 cites W2135829349 @default.
• W3119184430 cites W2139502131 @default.
• W3119184430 cites W2149898053 @default.
• W3119184430 cites W2155589041 @default.
• W3119184430 cites W2161509677 @default.
• W3119184430 cites W2163472335 @default.
• W3119184430 cites W2163751922 @default.
• W3119184430 cites W2259568072 @default.
• W3119184430 cites W2292481668 @default.
• W3119184430 cites W244649110 @default.
• W3119184430 cites W2521079522 @default.
• W3119184430 cites W2523500552 @default.
• W3119184430 cites W2583435206 @default.
• W3119184430 cites W2586450864 @default.
• W3119184430 cites W2587902106 @default.
• W3119184430 cites W2606467123 @default.
• W3119184430 cites W2614692161 @default.
• W3119184430 cites W2750813515 @default.
• W3119184430 cites W2760793316 @default.
• W3119184430 cites W2762949204 @default.
• W3119184430 cites W2791597830 @default.
• W3119184430 cites W2802425064 @default.
• W3119184430 cites W2806242691 @default.
• W3119184430 cites W2898125199 @default.
• W3119184430 cites W2910621475 @default.
• W3119184430 cites W2915782762 @default.
• W3119184430 cites W2916353478 @default.
• W3119184430 cites W2934045422 @default.
• W3119184430 cites W2943003842 @default.
• W3119184430 cites W2944714885 @default.
• W3119184430 cites W2946360658 @default.
• W3119184430 cites W2954856486 @default.
• W3119184430 cites W2955961631 @default.
• W3119184430 cites W2959271649 @default.
• W3119184430 cites W2994968453 @default.

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