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- W3119188846 abstract "The clinical progression of B cell chronic lymphocytic leukemia (CLL) is associated with immune cell dysfunction and a strong decrease of miR-181b-5p (miR-181b), promoting the death of CLL cells. Here we investigated whether the reduction of miR-181b impairs the immune response in CLL. We demonstrate that activated CD4+ T cells increase miR-181b expression in CLL through CD40–CD40L signaling, which enhances the maturation and activity of cytotoxic T cells and, consequently, the apoptotic response of CLL cells. The cytotoxic response is facilitated by a depletion of the anti-inflammatory cytokine interleukin 10, targeted by miR-181b. In vivo experiments in NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice confirmed that miR-181b promotes the apoptotic death of CLL cells only when functional T cells are restored. Overall, our findings suggest that the reinstatement of miR-181b in CLL cells could be an exploitable adjuvant therapeutic option for the treatment of CLL." @default.
- W3119188846 created "2021-01-18" @default.
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- W3119188846 date "2021-01-12" @default.
- W3119188846 modified "2023-09-26" @default.
- W3119188846 title "Enhanced Expression of miR-181b in B Cells of CLL Improves the Anti-Tumor Cytotoxic T Cell Response" @default.
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- W3119188846 doi "https://doi.org/10.3390/cancers13020257" @default.
- W3119188846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7826592" @default.
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