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• W3119197419 startingPage "e0243554" @default.
• W3119197419 abstract "With COVID-19 N95 shortages, frontline medical personnel are forced to reuse this disposable–but sophisticated–multilayer respirator. Widely used to decontaminate nonporous surfaces, UV-C light has demonstrated germicidal efficacy on porous, non-planar N95 respirators when all surfaces receive ≥1.0 J/cm 2 dose. Of utmost importance across disciplines, translation of empirical evidence to implementation relies upon UV-C measurements frequently confounded by radiometer complexities. To enable rigorous on-respirator measurements, we introduce a photochromic indicator dose quantification technique for: (1) UV-C treatment design and (2) in-process UV-C dose validation. While addressing outstanding indicator limitations of qualitative readout and insufficient dynamic range, our methodology establishes that color-changing dosimetry can achieve the necessary accuracy (>90%), uncertainty (<10%), and UV-C specificity (>95%) required for UV-C dose measurements. In a measurement infeasible with radiometers, we observe a striking ~20× dose variation over N95s within one decontamination system. Furthermore, we adapt consumer electronics for accessible quantitative readout and use optical attenuators to extend indicator dynamic range >10× to quantify doses relevant for N95 decontamination. By transforming photochromic indicators into quantitative dosimeters, we illuminate critical considerations for both photochromic indicators themselves and UV-C decontamination processes." @default.
• W3119197419 created "2021-01-18" @default.
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• W3119197419 date "2021-01-06" @default.
• W3119197419 modified "2023-09-26" @default.
• W3119197419 title "Quantitative UV-C dose validation with photochromic indicators for informed N95 emergency decontamination" @default.
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• W3119197419 doi "https://doi.org/10.1371/journal.pone.0243554" @default.
• W3119197419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7787392" @default.
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