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- W3119202143 abstract "Optical sorting holds great potential in precise biomolecule separation. However, the current approaches still face challenges to separate nanoscale biomolecules in a continuous manner. Here we report an integrated microfluidic-nanophotonic platform, named SWANS (Silicon Waveguide-pair Array-based Nanophotonic Sorting), for continuous sorting of nanoscale biomolecules. The platform leveraged the back-and-forth light coupling in waveguide-pair arrays to create a near-field optical lattice. Particles in the near-field lattice experienced recurring trapping and deflection events and eventually established distinct trajectories. The sorting mechanism was studied through theoretical analysis and the trajectory experiment of individual 200-nm and 500-nm particles. To validate the SWANS platform, the mixture of 200-nm, 300-nm and 500-nm particles, as well as the mixture of S. aureus and 100-nm particle was separated massively. The results confirmed sorting efficiency of 95.4 % and 85.7 % for 500-nm particles and S. aureus, respectively. The SWANS platform provides new avenues for continuous biomolecule separation and is anticipated to facilitate broad biomedical applications." @default.
- W3119202143 created "2021-01-18" @default.
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- W3119202143 date "2021-03-01" @default.
- W3119202143 modified "2023-10-06" @default.
- W3119202143 title "Continuous optical sorting of nanoscale biomolecules in integrated microfluidic-nanophotonic chips" @default.
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- W3119202143 doi "https://doi.org/10.1016/j.snb.2020.129428" @default.
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