FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119208515> ?p ?o ?g. }

• W3119208515 abstract "Abstract While numerous techniques can be used to measure and analyze insulin secretion in isolated islets in culture, assessments of insulin secretion in vivo are typically indirect and only semiquantitative. The CpepSfGFP reporter mouse line allows the in vivo imaging of insulin secretion from individual islets after a glucose stimulation, in live, anesthetized mice. Imaging the whole pancreas at high resolution in live mice to track the response of each individual islet over time includes numerous technical challenges and previous reports were only limited in scope and non-quantitative. Elaborating on this previous model—through the development of an improved methodology addressing anesthesia, temperature control and motion blur—we were able to track and quantify longitudinally insulin content throughout a glucose challenge in up to two hundred individual islets simultaneously. Through this approach we demonstrate quantitatively for the first time that while isolated islets respond homogeneously to glucose in culture, their profiles differ significantly in vivo. Independent of size or location, some islets respond sharply to a glucose stimulation while others barely secrete at all. This platform therefore provides a powerful approach to study the impact of disease, diet, surgery or pharmacological treatments on insulin secretion in the intact pancreas in vivo." @default.
• W3119208515 created "2021-01-18" @default.
• W3119208515 creator A5001472323 @default.
• W3119208515 creator A5015348180 @default.
• W3119208515 creator A5065488328 @default.
• W3119208515 creator A5072170846 @default.
• W3119208515 date "2021-01-12" @default.
• W3119208515 modified "2023-10-12" @default.
• W3119208515 title "Improved in vivo imaging method for individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose" @default.
• W3119208515 cites W1552235434 @default.
• W3119208515 cites W1969868761 @default.
• W3119208515 cites W1975941334 @default.
• W3119208515 cites W1992398173 @default.
• W3119208515 cites W1993719296 @default.
• W3119208515 cites W1996181748 @default.
• W3119208515 cites W1999072675 @default.
• W3119208515 cites W2000373551 @default.
• W3119208515 cites W2001105216 @default.
• W3119208515 cites W2011747410 @default.
• W3119208515 cites W2037496742 @default.
• W3119208515 cites W2042815240 @default.
• W3119208515 cites W2050739080 @default.
• W3119208515 cites W2055599620 @default.
• W3119208515 cites W2057505735 @default.
• W3119208515 cites W2058355180 @default.
• W3119208515 cites W2062231784 @default.
• W3119208515 cites W2068804274 @default.
• W3119208515 cites W2079630881 @default.
• W3119208515 cites W2080315484 @default.
• W3119208515 cites W2084228234 @default.
• W3119208515 cites W2084572092 @default.
• W3119208515 cites W2091125124 @default.
• W3119208515 cites W2099540110 @default.
• W3119208515 cites W2108371992 @default.
• W3119208515 cites W2110578074 @default.
• W3119208515 cites W2112573165 @default.
• W3119208515 cites W2112754181 @default.
• W3119208515 cites W2126229699 @default.
• W3119208515 cites W2140402299 @default.
• W3119208515 cites W2146877877 @default.
• W3119208515 cites W2150095569 @default.
• W3119208515 cites W2155006762 @default.
• W3119208515 cites W2157865424 @default.
• W3119208515 cites W2159733957 @default.
• W3119208515 cites W2167279371 @default.
• W3119208515 cites W2198859596 @default.
• W3119208515 cites W2205277535 @default.
• W3119208515 cites W2284351942 @default.
• W3119208515 cites W2295039318 @default.
• W3119208515 cites W2296189094 @default.
• W3119208515 cites W2306687011 @default.
• W3119208515 cites W2335958328 @default.
• W3119208515 cites W2413555945 @default.
• W3119208515 cites W2510449858 @default.
• W3119208515 cites W2602697787 @default.
• W3119208515 cites W2790501791 @default.
• W3119208515 cites W2806288388 @default.
• W3119208515 cites W2947526421 @default.
• W3119208515 cites W2950232203 @default.
• W3119208515 cites W2952797006 @default.
• W3119208515 cites W2983482279 @default.
• W3119208515 cites W3016685358 @default.
• W3119208515 cites W3037515906 @default.
• W3119208515 doi "https://doi.org/10.1038/s41598-020-79727-8" @default.
• W3119208515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7804140" @default.
• W3119208515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33436691" @default.
• W3119208515 hasPublicationYear "2021" @default.
• W3119208515 type Work @default.
• W3119208515 sameAs 3119208515 @default.
• W3119208515 citedByCount "5" @default.
• W3119208515 countsByYear W31192085152020 @default.
• W3119208515 countsByYear W31192085152021 @default.
• W3119208515 countsByYear W31192085152022 @default.
• W3119208515 crossrefType "journal-article" @default.
• W3119208515 hasAuthorship W3119208515A5001472323 @default.
• W3119208515 hasAuthorship W3119208515A5015348180 @default.
• W3119208515 hasAuthorship W3119208515A5065488328 @default.
• W3119208515 hasAuthorship W3119208515A5072170846 @default.
• W3119208515 hasBestOaLocation W31192085151 @default.
• W3119208515 hasConcept C126322002 @default.
• W3119208515 hasConcept C134018914 @default.
• W3119208515 hasConcept C150903083 @default.
• W3119208515 hasConcept C165220095 @default.
• W3119208515 hasConcept C207001950 @default.
• W3119208515 hasConcept C24998067 @default.
• W3119208515 hasConcept C2778764654 @default.
• W3119208515 hasConcept C2779306644 @default.
• W3119208515 hasConcept C2779855799 @default.
• W3119208515 hasConcept C29331040 @default.
• W3119208515 hasConcept C49039625 @default.
• W3119208515 hasConcept C71924100 @default.
• W3119208515 hasConcept C86803240 @default.
• W3119208515 hasConceptScore W3119208515C126322002 @default.
• W3119208515 hasConceptScore W3119208515C134018914 @default.
• W3119208515 hasConceptScore W3119208515C150903083 @default.
• W3119208515 hasConceptScore W3119208515C165220095 @default.
• W3119208515 hasConceptScore W3119208515C207001950 @default.
• W3119208515 hasConceptScore W3119208515C24998067 @default.
• W3119208515 hasConceptScore W3119208515C2778764654 @default.
• W3119208515 hasConceptScore W3119208515C2779306644 @default.

• next