Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119242519> ?p ?o ?g. }
- W3119242519 abstract "Abstract Background Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, because it is so aggressive with shorter survival. Chemotherapy remains the standard treatment due to the lack of specific and effective molecular targets. The aim of the present study is to investigate the potential roles of A Disintegrin and Metalloproteinase 10 (ADAM10) on TNBC cells and the effects of combining ADAM10 expression and neoadjuvant chemotherapy treatment (NACT) to improve the overall survival in breast cancer patients. Methods Using a series of breast cancer cell lines, we measured the expression of ADAM10 and its substrates by quantitative real-time PCR assay (qRT-PCR) and western blot analysis. Cell migration and invasion, cell proliferation, drug sensitivity assay, cell cycle and apoptosis were conducted in MDA-MB-231 cells cultured with ADAM10 siRNA. The effect of ADAM10 down-regulation by siRNA on its substrates was assessed by western blot analysis. We performed immunohistochemical staining for ADAM10 in clinical breast cancer tissues in 94 patients receiving NACT. Results The active form of ADAM10 was highly expressed in TNBC cell lines. Knockdown of ADAM10 in MDA-MB-231 cells led to a significant decrease in cell proliferation, migration, invasion and the IC 50 value of paclitaxel and adriamycin, while induced cell cycle arrest and apoptosis. And these changes were correlated with down-regulation of Notch signaling, CD44 and cellular prion protein (PrPc). In clinical breast cancer cases, a high ADAM10 expression in pre-NACT samples was strongly associated with poorer response to NACT and shorter overall survival. Conclusions These data suggest the previously unrecognized roles of ADAM10 in contributing to the progression and chemo-resistance of TNBC." @default.
- W3119242519 created "2021-01-18" @default.
- W3119242519 creator A5005719638 @default.
- W3119242519 creator A5008420458 @default.
- W3119242519 creator A5017470687 @default.
- W3119242519 creator A5024664435 @default.
- W3119242519 creator A5039266487 @default.
- W3119242519 creator A5066204135 @default.
- W3119242519 creator A5081736415 @default.
- W3119242519 creator A5082008959 @default.
- W3119242519 creator A5082912235 @default.
- W3119242519 creator A5083473885 @default.
- W3119242519 date "2021-01-07" @default.
- W3119242519 modified "2023-10-18" @default.
- W3119242519 title "ADAM10 is involved in the oncogenic process and chemo-resistance of triple-negative breast cancer via regulating Notch1 signaling pathway, CD44 and PrPc" @default.
- W3119242519 cites W1506037014 @default.
- W3119242519 cites W1556478890 @default.
- W3119242519 cites W1580230845 @default.
- W3119242519 cites W1789716240 @default.
- W3119242519 cites W1899950673 @default.
- W3119242519 cites W1969915666 @default.
- W3119242519 cites W1980083899 @default.
- W3119242519 cites W1992535168 @default.
- W3119242519 cites W1992660677 @default.
- W3119242519 cites W2004419844 @default.
- W3119242519 cites W2018868898 @default.
- W3119242519 cites W2022745640 @default.
- W3119242519 cites W2023753181 @default.
- W3119242519 cites W2027342390 @default.
- W3119242519 cites W2045778975 @default.
- W3119242519 cites W2049106924 @default.
- W3119242519 cites W2050161704 @default.
- W3119242519 cites W2050761481 @default.
- W3119242519 cites W2062711358 @default.
- W3119242519 cites W2074257134 @default.
- W3119242519 cites W2080737967 @default.
- W3119242519 cites W2088682566 @default.
- W3119242519 cites W2093498736 @default.
- W3119242519 cites W2096283457 @default.
- W3119242519 cites W2101804968 @default.
- W3119242519 cites W2116347075 @default.
- W3119242519 cites W2123396024 @default.
- W3119242519 cites W2129239398 @default.
- W3119242519 cites W2130038947 @default.
- W3119242519 cites W2131659449 @default.
- W3119242519 cites W2132810311 @default.
- W3119242519 cites W2145837099 @default.
- W3119242519 cites W2149152049 @default.
- W3119242519 cites W2152979067 @default.
- W3119242519 cites W2163857222 @default.
- W3119242519 cites W2167587342 @default.
- W3119242519 cites W2194650865 @default.
- W3119242519 cites W2297865359 @default.
- W3119242519 cites W2755013718 @default.
- W3119242519 cites W2893354345 @default.
- W3119242519 cites W2901584229 @default.
- W3119242519 cites W2908616666 @default.
- W3119242519 cites W2911718257 @default.
- W3119242519 cites W2924020944 @default.
- W3119242519 cites W2959248466 @default.
- W3119242519 doi "https://doi.org/10.1186/s12935-020-01727-5" @default.
- W3119242519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7791678" @default.
- W3119242519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33413403" @default.
- W3119242519 hasPublicationYear "2021" @default.
- W3119242519 type Work @default.
- W3119242519 sameAs 3119242519 @default.
- W3119242519 citedByCount "17" @default.
- W3119242519 countsByYear W31192425192021 @default.
- W3119242519 countsByYear W31192425192022 @default.
- W3119242519 countsByYear W31192425192023 @default.
- W3119242519 crossrefType "journal-article" @default.
- W3119242519 hasAuthorship W3119242519A5005719638 @default.
- W3119242519 hasAuthorship W3119242519A5008420458 @default.
- W3119242519 hasAuthorship W3119242519A5017470687 @default.
- W3119242519 hasAuthorship W3119242519A5024664435 @default.
- W3119242519 hasAuthorship W3119242519A5039266487 @default.
- W3119242519 hasAuthorship W3119242519A5066204135 @default.
- W3119242519 hasAuthorship W3119242519A5081736415 @default.
- W3119242519 hasAuthorship W3119242519A5082008959 @default.
- W3119242519 hasAuthorship W3119242519A5082912235 @default.
- W3119242519 hasAuthorship W3119242519A5083473885 @default.
- W3119242519 hasBestOaLocation W31192425191 @default.
- W3119242519 hasConcept C109523444 @default.
- W3119242519 hasConcept C121608353 @default.
- W3119242519 hasConcept C126322002 @default.
- W3119242519 hasConcept C143998085 @default.
- W3119242519 hasConcept C1491633281 @default.
- W3119242519 hasConcept C161879069 @default.
- W3119242519 hasConcept C170493617 @default.
- W3119242519 hasConcept C173396325 @default.
- W3119242519 hasConcept C190283241 @default.
- W3119242519 hasConcept C2777292972 @default.
- W3119242519 hasConcept C2778259572 @default.
- W3119242519 hasConcept C2778715156 @default.
- W3119242519 hasConcept C2780110267 @default.
- W3119242519 hasConcept C2780932548 @default.
- W3119242519 hasConcept C29537977 @default.
- W3119242519 hasConcept C502942594 @default.
- W3119242519 hasConcept C530470458 @default.
- W3119242519 hasConcept C54355233 @default.