FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119245108> ?p ?o ?g. }

• W3119245108 endingPage "12" @default.
• W3119245108 startingPage "1" @default.
• W3119245108 abstract "Background. The tumor-infiltrating immune cells are closely associated with the prognosis of gastric cancer (GC). This article is aimed at determining the composition change of immune cells and immune regulatory factors in GC and normal tissues, depicting their prognosis value in GC, and revealing the relationship between them and GC clinical parameters. Methods. We used CIBERSORT to calculate the proportion of 22 immune cells in the GC or normal tissues; a <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>t</mi> </math> -test was applied to assess the expression difference of immune cells and immune regulatory factors in normal and GC tissues. The relationship of the immune cells, immune regulatory factors, and GC patients’ clinical characteristics was assessed by univariate analysis. Results. In this study, we found that the proportion of macrophages increased, while plasma cells and monocytes decreased in GC tissues. In these immune fractions, Tregs and naïve B cells were found to be correlated with GC patients’ prognosis. Interestingly, the expression of immune regulatory factors was ambiguous with their classical function in GC tissues. For example, TIM-3, FOXP3, and CMTM6 were overexpressed, while CD27 and PD-1 were underexpressed in GC tissues. We also found that IDO1, PD-1, TIGIT, and TIM-3 were highly expressed in high-grade GC tissues, the HERC2 expression level was related to patients’ gender, and the TIGIT expression level was sensitive to targeted therapy. Furthermore, our results suggested that the infiltration of Tregs and naive B cells was strongly correlated with the T stage, radiation therapy, targeted molecular therapy, and the expression levels of TIM-3 and FOXP3 in GC. Conclusion. The expression pattern of tumor-infiltrating immune cells and immune regulatory factors was systematically depicted in the GC tumor microenvironment, indicating that individualized treatment based on the tumor-infiltrating immune cells and immune regulatory factors may be beneficial to GC patients." @default.
• W3119245108 created "2021-01-18" @default.
• W3119245108 creator A5017467042 @default.
• W3119245108 creator A5022600937 @default.
• W3119245108 creator A5027943437 @default.
• W3119245108 creator A5038414071 @default.
• W3119245108 creator A5040522603 @default.
• W3119245108 creator A5044513573 @default.
• W3119245108 creator A5046560835 @default.
• W3119245108 creator A5049692788 @default.
• W3119245108 creator A5070287856 @default.
• W3119245108 creator A5071444643 @default.
• W3119245108 creator A5089744573 @default.
• W3119245108 date "2021-01-09" @default.
• W3119245108 modified "2023-10-16" @default.
• W3119245108 title "Immune Cell Landscape in Gastric Cancer" @default.
• W3119245108 cites W1969179435 @default.
• W3119245108 cites W1971620413 @default.
• W3119245108 cites W2084605252 @default.
• W3119245108 cites W2201278844 @default.
• W3119245108 cites W2293550045 @default.
• W3119245108 cites W2303799488 @default.
• W3119245108 cites W2311746741 @default.
• W3119245108 cites W2341432578 @default.
• W3119245108 cites W2560339139 @default.
• W3119245108 cites W2564373764 @default.
• W3119245108 cites W2568773821 @default.
• W3119245108 cites W2594205397 @default.
• W3119245108 cites W2597613988 @default.
• W3119245108 cites W2600285053 @default.
• W3119245108 cites W2735126203 @default.
• W3119245108 cites W2742444627 @default.
• W3119245108 cites W2747359356 @default.
• W3119245108 cites W2749553776 @default.
• W3119245108 cites W2767645660 @default.
• W3119245108 cites W2772467227 @default.
• W3119245108 cites W2788142646 @default.
• W3119245108 cites W2803332907 @default.
• W3119245108 cites W2890798397 @default.
• W3119245108 cites W2896438622 @default.
• W3119245108 cites W2897230620 @default.
• W3119245108 cites W2899221562 @default.
• W3119245108 cites W2911456342 @default.
• W3119245108 cites W2918500142 @default.
• W3119245108 cites W2936599984 @default.
• W3119245108 cites W2940171567 @default.
• W3119245108 cites W2940561057 @default.
• W3119245108 cites W2944023112 @default.
• W3119245108 cites W2946138597 @default.
• W3119245108 cites W2947171117 @default.
• W3119245108 cites W2980537095 @default.
• W3119245108 cites W2981147981 @default.
• W3119245108 cites W2989633600 @default.
• W3119245108 cites W3000218019 @default.
• W3119245108 cites W3004649412 @default.
• W3119245108 cites W3007744706 @default.
• W3119245108 cites W3010987288 @default.
• W3119245108 cites W3012148640 @default.
• W3119245108 cites W3043901339 @default.
• W3119245108 cites W3044098051 @default.
• W3119245108 cites W3047225502 @default.
• W3119245108 cites W3047756933 @default.
• W3119245108 cites W3081152304 @default.
• W3119245108 doi "https://doi.org/10.1155/2021/1930706" @default.
• W3119245108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7857889" @default.
• W3119245108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33575321" @default.
• W3119245108 hasPublicationYear "2021" @default.
• W3119245108 type Work @default.
• W3119245108 sameAs 3119245108 @default.
• W3119245108 citedByCount "7" @default.
• W3119245108 countsByYear W31192451082021 @default.
• W3119245108 countsByYear W31192451082022 @default.
• W3119245108 countsByYear W31192451082023 @default.
• W3119245108 crossrefType "journal-article" @default.
• W3119245108 hasAuthorship W3119245108A5017467042 @default.
• W3119245108 hasAuthorship W3119245108A5022600937 @default.
• W3119245108 hasAuthorship W3119245108A5027943437 @default.
• W3119245108 hasAuthorship W3119245108A5038414071 @default.
• W3119245108 hasAuthorship W3119245108A5040522603 @default.
• W3119245108 hasAuthorship W3119245108A5044513573 @default.
• W3119245108 hasAuthorship W3119245108A5046560835 @default.
• W3119245108 hasAuthorship W3119245108A5049692788 @default.
• W3119245108 hasAuthorship W3119245108A5070287856 @default.
• W3119245108 hasAuthorship W3119245108A5071444643 @default.
• W3119245108 hasAuthorship W3119245108A5089744573 @default.
• W3119245108 hasBestOaLocation W31192451081 @default.
• W3119245108 hasConcept C121608353 @default.
• W3119245108 hasConcept C203014093 @default.
• W3119245108 hasConcept C2776090121 @default.
• W3119245108 hasConcept C2779118045 @default.
• W3119245108 hasConcept C2779727006 @default.
• W3119245108 hasConcept C502942594 @default.
• W3119245108 hasConcept C54355233 @default.
• W3119245108 hasConcept C86803240 @default.
• W3119245108 hasConcept C8891405 @default.
• W3119245108 hasConceptScore W3119245108C121608353 @default.
• W3119245108 hasConceptScore W3119245108C203014093 @default.
• W3119245108 hasConceptScore W3119245108C2776090121 @default.

• next