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• W3119246756 endingPage "102920" @default.
• W3119246756 startingPage "102920" @default.
• W3119246756 abstract "Thyroid carcinoma is the most common endocrine tumor, and thyroid papillary carcinoma is the most common form. Although thyroid papillary carcinoma presents a good prognosis, some patients still exhibit recurrence or distant metastasis. miR-1301-3p has been found involved in the occurrence and development of some special tumors. Our study aims to investigate the miR-1301-3p expression in thyroid papillary carcinoma, to explore its biological function, and to provide a potential marker for diagnosis and treatment of thyroid papillary carcinoma. The tissue samples from 70 patients with PTC (n = 35) and benign tumors (n = 35) were collected respectively. miR-1301-3p expression were detected by qPCR. Diagnostic value of miR-1301-3p was analyzed by ROC curve. CCK-8 assays and flow cytometry were performed to detect the effect of miR-1301-3p on TPC-1 function. PCNA expression of protein was detected by WB. Compared with the normal group, the expression of miR-1301-3p was obviously decreased in both benign group and PTC group. With the higher T and N grades, the lower expression of miR-1301-3p. ROC curve analysis showed that the diagnostic values of miR-1301-3p for benign tumor and PTC were 0.766 and 0.881, respectively. Vitro experiments showed that miR-1301-3p was decreased in TPC-1 cells, then, upregulated miR-1301-3p blocked the TPC-1 cell cycle in G1/S phase, and inhibited the proliferation. PCNA expression was significantly increased in TPC-1 cells and significantly decreased after upregulation of miR-1301-3p. The present study showed that the expression of miR-1301-3p in PTC was significantly decreased, which was related to T and N grade. Upregulation of miR-1301-3p could inhibit cell proliferation and cell migration. miR-1301-3p may serve as a potential biomarker for the early diagnosis and treatment of PTC." @default.
• W3119246756 created "2021-01-18" @default.
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• W3119246756 date "2021-03-01" @default.
• W3119246756 modified "2023-10-18" @default.
• W3119246756 title "miR-1301-3p suppresses tumor growth by downregulating PCNA in thyroid papillary cancer" @default.
• W3119246756 cites W1972755526 @default.
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• W3119246756 doi "https://doi.org/10.1016/j.amjoto.2021.102920" @default.
• W3119246756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33454555" @default.
• W3119246756 hasPublicationYear "2021" @default.
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