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- W3119247605 startingPage "63" @default.
- W3119247605 abstract "Jumbo phages have attracted much attention by virtue of their extraordinary genome size and unusual aspects of biology. By performing a comparative genomics analysis of 224 jumbo phages, we suggest an objective inclusion criterion based on genome size distributions and present a synthetic overview of their manifold adaptations across major biological systems. By means of clustering and principal component analysis of the phyletic patterns of conserved genes, all known jumbo phages can be classified into three higher-order groups, which include both myoviral and siphoviral morphologies indicating multiple independent origins from smaller predecessors. Our study uncovers several under-appreciated or unreported aspects of the DNA replication, recombination, transcription and virion maturation systems. Leveraging sensitive sequence analysis methods, we identify novel protein-modifying enzymes that might help hijack the host-machinery. Focusing on host–virus conflicts, we detect strategies used to counter different wings of the bacterial immune system, such as cyclic nucleotide- and NAD+-dependent effector-activation, and prevention of superinfection during pseudolysogeny. We reconstruct the RNA-repair systems of jumbo phages that counter the consequences of RNA-targeting host effectors. These findings also suggest that several jumbo phage proteins provide a snapshot of the systems found in ancient replicons preceding the last universal ancestor of cellular life." @default.
- W3119247605 created "2021-01-18" @default.
- W3119247605 creator A5004461127 @default.
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- W3119247605 creator A5026932356 @default.
- W3119247605 creator A5035311982 @default.
- W3119247605 creator A5045663522 @default.
- W3119247605 date "2021-01-05" @default.
- W3119247605 modified "2023-10-15" @default.
- W3119247605 title "Jumbo Phages: A Comparative Genomic Overview of Core Functions and Adaptions for Biological Conflicts" @default.
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