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- W3119248077 endingPage "103516" @default.
- W3119248077 startingPage "103516" @default.
- W3119248077 abstract "The T-box genes are essential transcription factors during limb development. In Drosophila, Dorsocross (Doc) and optomotor-blind (omb), members of the Tbx2 and Tbx6 families, are best studied in the Drosophila wing development. Despite prominently expressed in leg discs, the specific function of these genes in leg growth is still not revealed. Here we demonstrated that Doc and omb regulated the morphogenesis of leg intermediate regions in a functionally redundant manner. Loss of Doc or omb individually did not result in any developmental defects of the legs, but loss of both genes induced significant defects in femur and proximal tibia of the adult legs. These genes located in the dorsal domain, where the Doc region expanded and cross-overlapped with the omb region corresponding to the presumptive leg intermediate region. We detected that the normal epithelial folds in the leg discs were disrupted along with dorsal repression of cell proliferation and activation of cell apoptosis when Doc and omb were both reduced. Furthermore, the dorsal expression of dachshund (dac), a canonical leg developmental gene specifying the leg intermediate region, was maintained by Doc and omb. Meanwhile, the Notch pathway was compromised in the dorsal domain when these genes were reduced, which might contribute to the joint defect of the adult leg intermediate regions. Our study provides cytological and genetic evidence for understanding the redundant function of Doc and omb in leg morphogenesis." @default.
- W3119248077 created "2021-01-18" @default.
- W3119248077 creator A5011088053 @default.
- W3119248077 creator A5016154595 @default.
- W3119248077 creator A5045486164 @default.
- W3119248077 creator A5058380236 @default.
- W3119248077 date "2021-02-01" @default.
- W3119248077 modified "2023-10-01" @default.
- W3119248077 title "T-box transcription factors Dorsocross and optomotor-blind control Drosophila leg patterning in a functionally redundant manner" @default.
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- W3119248077 doi "https://doi.org/10.1016/j.ibmb.2020.103516" @default.
- W3119248077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33412239" @default.
- W3119248077 hasPublicationYear "2021" @default.
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