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- W3119261006 abstract "Abstract Salivary gland stones, or sialoliths, are the most common cause of the obstruction of salivary glands. Symptomatic sialolithiasis has a prevalence of 0.45% in the general population, is characterized by recurrent painful periprandial swelling of the affected gland and often results in sialadenitis with the need for surgical intervention. The mechanism behind the formation of sialoliths has been elusive. Here we show that neutrophil extracellular traps (NETs) initiate the formation and growth of sialoliths. The deposition of neutrophil granulocyte extracellular DNA around small crystals results in their dense aggregation, and the subsequent mineralization creates alternating layers of dense mineral, predominantly calcium salt deposits and DNA. Further agglomeration and appositional growth of these structures promotes the development of macroscopic sialoliths that finally occlude the efferent ducts of the salivary glands, causing clinical symptoms and salivary gland dysfunction. These findings provide an entirely novel insight into the mechanism of sialolithogenesis in which an immune system mediated response essentially participates in the physico-chemical process of concrement formation and growth." @default.
- W3119261006 created "2021-01-18" @default.
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- W3119261006 date "2020-08-14" @default.
- W3119261006 modified "2023-10-08" @default.
- W3119261006 title "Development and Growth of Human Salivary Stones by Neutrophil Extracellular Traps" @default.
- W3119261006 doi "https://doi.org/10.21203/rs.3.rs-47256/v1" @default.
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