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• W31192620 abstract "In higher mammals, the primary visual pathway starts with the (retinogeniculate) projection from the retina to the dorsal lateral geniculate nucleus (dLGN) of the thalamus, which in turn projects to visual cortex. Although the retinal axons initially innervate the dLGN in a relatively disorganized manner, they are precisely arranged by maturity. Some dominant features of this organization emerge only under the influence of activity, yet these features are established before eye-opening or photoreceptor function. The crucial activity is supplied by spontaneous bursts of action potentials that propagate in waves across the immature retinal ganglion cell layer that projects to the dLGN. Under the influence of retinal activity, the retinal axons segregate into eye-specific layers, on/off sublayers, and precise retinotopic maps.This dissertation describes a formal computational framework for modeling and exploring the activity-dependent development of the retinogeniculate projection. The model is the first to support the development of layers, sublayers, and retinotopy in a unified framework. The model is constructed so as to be directly biologically interpretable and predictive. It refines based on realistic patterns of wave activity, retinal axon arbor change, and Hebbian synaptic weight change. In addition, the model is relatively tractable to formal analysis. This tractability makes the model relatively undemanding to simulate computationally and provides analytic insight into the dynamics of the model refinement. Several experimental predictions that follow directly from the model are described." @default.
• W31192620 created "2016-06-24" @default.
• W31192620 creator A5036330110 @default.
• W31192620 creator A5066230293 @default.
• W31192620 date "1998-01-01" @default.
• W31192620 modified "2023-09-27" @default.
• W31192620 title "Modeling activity-dependent development in the retinogeniculate projection" @default.
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