FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119268002> ?p ?o ?g. }

• W3119268002 endingPage "111245" @default.
• W3119268002 startingPage "111245" @default.
• W3119268002 abstract "In healthy individuals, a major factor influencing the heart rate variability (HRV) is the circadian rhythm. The role of melatonin as an essential component of the circadian rhythm in the adult human organism and the beneficial effects of a treatment with melatonin during the fetal period is well described. Toxic effects of melatonin are discussed less frequently. Since pharmacological studies cannot be carried out on pregnant women, the establishment of an equivalent in vitro model is important. We therefore tested whether melatonin can influence the beat rate variability (BRV) of spontaneously beating cardiomyocytes derived from murine embryonic stem cells (mESCs) and whether melatonin exhibits toxic effects in this in vitro model. Microelectrode Arrays recorded extracellular field potentials of spontaneously beating cardiomyocytes. Melatonin was applied in a concentration range from 10−11 M to 10–5 M. The analysis of the BRV focused on time domain methods. In line with clinical observations, melatonin decreased the beating frequency and increased the BRV. The effect of melatonin up to a concentration of 10−6 M was reversible, whereas the application of higher concentrations induced an irreversible effect. The study underlines the potential of this in vitro model to help explore the development of circadian rhythms and their modulation by melatonin in the embryonic phase. The results imply that melatonin influences the heart rhythm as early as during the embryonic heart development. Furthermore, the results indicate a potentially toxic effect of melatonin that has not been described in detail before." @default.
• W3119268002 created "2021-01-18" @default.
• W3119268002 creator A5003778167 @default.
• W3119268002 creator A5035399483 @default.
• W3119268002 creator A5071484811 @default.
• W3119268002 creator A5083746732 @default.
• W3119268002 creator A5086802099 @default.
• W3119268002 date "2021-04-01" @default.
• W3119268002 modified "2023-10-16" @default.
• W3119268002 title "The influence of melatonin on the heart rhythm – An in vitro simulation with murine embryonic stem cell derived cardiomyocytes" @default.
• W3119268002 cites W1967900132 @default.
• W3119268002 cites W1976414968 @default.
• W3119268002 cites W1978067743 @default.
• W3119268002 cites W1979478060 @default.
• W3119268002 cites W1995421025 @default.
• W3119268002 cites W2014512584 @default.
• W3119268002 cites W2026605955 @default.
• W3119268002 cites W2034348289 @default.
• W3119268002 cites W2060718153 @default.
• W3119268002 cites W2063746275 @default.
• W3119268002 cites W2083510568 @default.
• W3119268002 cites W2085805061 @default.
• W3119268002 cites W2091385411 @default.
• W3119268002 cites W2097319089 @default.
• W3119268002 cites W2100491180 @default.
• W3119268002 cites W2105571869 @default.
• W3119268002 cites W2106303814 @default.
• W3119268002 cites W2112393215 @default.
• W3119268002 cites W2122859962 @default.
• W3119268002 cites W2133472982 @default.
• W3119268002 cites W2136100283 @default.
• W3119268002 cites W2142059781 @default.
• W3119268002 cites W2167741567 @default.
• W3119268002 cites W2258897683 @default.
• W3119268002 cites W2263403818 @default.
• W3119268002 cites W2285072859 @default.
• W3119268002 cites W277593876 @default.
• W3119268002 cites W2804765607 @default.
• W3119268002 cites W2895967865 @default.
• W3119268002 cites W2977881654 @default.
• W3119268002 doi "https://doi.org/10.1016/j.biopha.2021.111245" @default.
• W3119268002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33450496" @default.
• W3119268002 hasPublicationYear "2021" @default.
• W3119268002 type Work @default.
• W3119268002 sameAs 3119268002 @default.
• W3119268002 citedByCount "5" @default.
• W3119268002 countsByYear W31192680022021 @default.
• W3119268002 countsByYear W31192680022022 @default.
• W3119268002 countsByYear W31192680022023 @default.
• W3119268002 crossrefType "journal-article" @default.
• W3119268002 hasAuthorship W3119268002A5003778167 @default.
• W3119268002 hasAuthorship W3119268002A5035399483 @default.
• W3119268002 hasAuthorship W3119268002A5071484811 @default.
• W3119268002 hasAuthorship W3119268002A5083746732 @default.
• W3119268002 hasAuthorship W3119268002A5086802099 @default.
• W3119268002 hasBestOaLocation W31192680021 @default.
• W3119268002 hasConcept C104317684 @default.
• W3119268002 hasConcept C121446783 @default.
• W3119268002 hasConcept C126322002 @default.
• W3119268002 hasConcept C134018914 @default.
• W3119268002 hasConcept C135343436 @default.
• W3119268002 hasConcept C145103041 @default.
• W3119268002 hasConcept C202751555 @default.
• W3119268002 hasConcept C2777837822 @default.
• W3119268002 hasConcept C2778182776 @default.
• W3119268002 hasConcept C2781269140 @default.
• W3119268002 hasConcept C55493867 @default.
• W3119268002 hasConcept C71924100 @default.
• W3119268002 hasConcept C86803240 @default.
• W3119268002 hasConceptScore W3119268002C104317684 @default.
• W3119268002 hasConceptScore W3119268002C121446783 @default.
• W3119268002 hasConceptScore W3119268002C126322002 @default.
• W3119268002 hasConceptScore W3119268002C134018914 @default.
• W3119268002 hasConceptScore W3119268002C135343436 @default.
• W3119268002 hasConceptScore W3119268002C145103041 @default.
• W3119268002 hasConceptScore W3119268002C202751555 @default.
• W3119268002 hasConceptScore W3119268002C2777837822 @default.
• W3119268002 hasConceptScore W3119268002C2778182776 @default.
• W3119268002 hasConceptScore W3119268002C2781269140 @default.
• W3119268002 hasConceptScore W3119268002C55493867 @default.
• W3119268002 hasConceptScore W3119268002C71924100 @default.
• W3119268002 hasConceptScore W3119268002C86803240 @default.
• W3119268002 hasLocation W31192680021 @default.
• W3119268002 hasOpenAccess W3119268002 @default.
• W3119268002 hasPrimaryLocation W31192680021 @default.
• W3119268002 hasRelatedWork W1505050831 @default.
• W3119268002 hasRelatedWork W1999707698 @default.
• W3119268002 hasRelatedWork W2009692691 @default.
• W3119268002 hasRelatedWork W2050416457 @default.
• W3119268002 hasRelatedWork W2066375555 @default.
• W3119268002 hasRelatedWork W2073747041 @default.
• W3119268002 hasRelatedWork W2092341993 @default.
• W3119268002 hasRelatedWork W2107832950 @default.
• W3119268002 hasRelatedWork W2133072077 @default.
• W3119268002 hasRelatedWork W78316155 @default.
• W3119268002 hasVolume "136" @default.
• W3119268002 isParatext "false" @default.
• W3119268002 isRetracted "false" @default.

• next