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- W3119287926 endingPage "102" @default.
- W3119287926 startingPage "91" @default.
- W3119287926 abstract "Since the early 2010s, cryo-electron microscopy (cryo-EM) has evolved to a mainstream structural biology method in what has been dubbed the resolution revolution. Pharma companies also began to use cryo-EM in drug discovery, evidenced by a growing number of industry publications. Hitherto limited in resolution, throughput and attainable molecular weight, cryo-EM is rapidly overcoming its main limitations for more widespread use through a new wave of technological advances. This review discusses how cryo-EM has already impacted drug discovery, and how the state-of-the-art is poised to further revolutionize its application to previously intractable proteins as well as new use cases." @default.
- W3119287926 created "2021-01-18" @default.
- W3119287926 creator A5017520525 @default.
- W3119287926 creator A5054209034 @default.
- W3119287926 creator A5091682466 @default.
- W3119287926 date "2020-12-01" @default.
- W3119287926 modified "2023-10-14" @default.
- W3119287926 title "The rapidly evolving role of cryo-EM in drug design" @default.
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- W3119287926 doi "https://doi.org/10.1016/j.ddtec.2020.12.003" @default.
- W3119287926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34895645" @default.
- W3119287926 hasPublicationYear "2020" @default.
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