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- W3119298500 endingPage "882" @default.
- W3119298500 startingPage "873" @default.
- W3119298500 abstract "A central goal of neuroscience research is to understand how experiences modify brain circuits to guide future adaptive behavior. In response to environmental stimuli, neural circuit activity engages gene regulatory mechanisms within each cell. This activity-dependent gene expression is governed, in part, by epigenetic processes that can produce persistent changes in both neural circuits and the epigenome itself. The complex interplay between circuit activity and neuronal gene regulation is vital to learning and memory, and, when disrupted, is linked to debilitating psychiatric conditions, such as substance use disorder. To develop clinical treatments, it is paramount to advance our understanding of how neural circuits and the epigenome cooperate to produce behavioral adaptation. Here, we discuss how new genetic tools, used to manipulate neural circuits and chromatin, have enabled the discovery of epigenetic processes that bring about long-lasting changes in behavior relevant to mental health and disease." @default.
- W3119298500 created "2021-01-18" @default.
- W3119298500 creator A5006378082 @default.
- W3119298500 creator A5017550855 @default.
- W3119298500 creator A5024036966 @default.
- W3119298500 creator A5030305869 @default.
- W3119298500 creator A5084569687 @default.
- W3119298500 creator A5090805805 @default.
- W3119298500 date "2021-01-14" @default.
- W3119298500 modified "2023-10-17" @default.
- W3119298500 title "From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health" @default.
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