FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119300143> ?p ?o ?g. }

• W3119300143 abstract "Abstract Objective To assess the positive predictive value (PPV) of noninvasive prenatal testing (NIPT) as a screening test for sex chromosome aneuploidy (SCA) with different maternal characteristics and prenatal decisions in positive cases. Materials and methods We retrospectively analysed 45,773 singleton pregnancies with different characteristics that were subjected to NIPT in the Maternity and Child Health Hospital of Anhui Province. The results were validated by karyotyping. Clinical data, diagnostic results, and data on pregnancy outcomes were collected. Results In total, 314 cases were SCA positive by NIPT; among those, 143 underwent invasive prenatal diagnostic testing, and 58 were true-positive. Overall, the PPVs for 45,X, 47,XXX, 47,XXY and 47,XYY were 12.5%, 51.72%, 66.67% and 83.33%, respectively. Interestingly, when only pregnant women of advanced maternal age (AMA) were screened, the PPVs for 45,X, 47,XXX, 47,XXY and 47,XYY were 23.81%, 53.33%, 78.95%, and 66.67%, respectively. The frequency of SCA was significantly higher in the AMA group than in the non-AMA group. The frequencies of 47,XXX and 47,XXY were significantly correlated with maternal age. Conclusion NIPT performed better in predicting sex chromosome trisomies than monosomy X, and patients with 45,X positive foetuses were more eager to terminate pregnancy than those with 47,XXX and 47,XYY. AMA may be a risk factor of having a foetus with SCA. Our findings may assist in genetic counselling of AMA pregnant women. Our pre- and posttest counselling are essential for familiarizing pregnant women with the benefits and limitations of NIPT, which may ease their anxiety and enable them to make informed choices for further diagnosis and pregnancy decisions." @default.
• W3119300143 created "2021-01-18" @default.
• W3119300143 creator A5004133331 @default.
• W3119300143 creator A5011192230 @default.
• W3119300143 creator A5041052990 @default.
• W3119300143 creator A5048389767 @default.
• W3119300143 creator A5056761594 @default.
• W3119300143 creator A5087262379 @default.
• W3119300143 date "2021-01-06" @default.
• W3119300143 modified "2023-10-14" @default.
• W3119300143 title "Noninvasive prenatal testing for assessing foetal sex chromosome aneuploidy: a retrospective study of 45,773 cases" @default.
• W3119300143 cites W1499684505 @default.
• W3119300143 cites W1881396234 @default.
• W3119300143 cites W1918408090 @default.
• W3119300143 cites W1924954658 @default.
• W3119300143 cites W1956706131 @default.
• W3119300143 cites W1993760253 @default.
• W3119300143 cites W2003835140 @default.
• W3119300143 cites W2008532258 @default.
• W3119300143 cites W2010267502 @default.
• W3119300143 cites W2057814045 @default.
• W3119300143 cites W2086426085 @default.
• W3119300143 cites W2100977485 @default.
• W3119300143 cites W2117753480 @default.
• W3119300143 cites W2258532034 @default.
• W3119300143 cites W2463477544 @default.
• W3119300143 cites W2598698772 @default.
• W3119300143 cites W2612179590 @default.
• W3119300143 cites W2747509285 @default.
• W3119300143 cites W2755113083 @default.
• W3119300143 cites W2764059671 @default.
• W3119300143 cites W2771351246 @default.
• W3119300143 cites W2783098393 @default.
• W3119300143 cites W2810083578 @default.
• W3119300143 cites W2886829783 @default.
• W3119300143 cites W2888080604 @default.
• W3119300143 cites W2892527237 @default.
• W3119300143 cites W2898496420 @default.
• W3119300143 cites W2909146979 @default.
• W3119300143 cites W2939707204 @default.
• W3119300143 cites W2945683499 @default.
• W3119300143 cites W2946241028 @default.
• W3119300143 cites W2955655720 @default.
• W3119300143 cites W2960610083 @default.
• W3119300143 cites W2981422404 @default.
• W3119300143 cites W2982703773 @default.
• W3119300143 cites W2990650357 @default.
• W3119300143 cites W3039478859 @default.
• W3119300143 cites W3083641967 @default.
• W3119300143 doi "https://doi.org/10.1186/s13039-020-00521-2" @default.
• W3119300143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7786464" @default.
• W3119300143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33407708" @default.
• W3119300143 hasPublicationYear "2021" @default.
• W3119300143 type Work @default.
• W3119300143 sameAs 3119300143 @default.
• W3119300143 citedByCount "14" @default.
• W3119300143 countsByYear W31193001432021 @default.
• W3119300143 countsByYear W31193001432022 @default.
• W3119300143 countsByYear W31193001432023 @default.
• W3119300143 crossrefType "journal-article" @default.
• W3119300143 hasAuthorship W3119300143A5004133331 @default.
• W3119300143 hasAuthorship W3119300143A5011192230 @default.
• W3119300143 hasAuthorship W3119300143A5041052990 @default.
• W3119300143 hasAuthorship W3119300143A5048389767 @default.
• W3119300143 hasAuthorship W3119300143A5056761594 @default.
• W3119300143 hasAuthorship W3119300143A5087262379 @default.
• W3119300143 hasBestOaLocation W31193001431 @default.
• W3119300143 hasConcept C104317684 @default.
• W3119300143 hasConcept C126322002 @default.
• W3119300143 hasConcept C131872663 @default.
• W3119300143 hasConcept C167135981 @default.
• W3119300143 hasConcept C172680121 @default.
• W3119300143 hasConcept C2776210078 @default.
• W3119300143 hasConcept C2776229224 @default.
• W3119300143 hasConcept C2776352029 @default.
• W3119300143 hasConcept C2778258057 @default.
• W3119300143 hasConcept C2779142324 @default.
• W3119300143 hasConcept C2779234561 @default.
• W3119300143 hasConcept C2779672484 @default.
• W3119300143 hasConcept C2780673598 @default.
• W3119300143 hasConcept C29456083 @default.
• W3119300143 hasConcept C30481170 @default.
• W3119300143 hasConcept C47042493 @default.
• W3119300143 hasConcept C53226629 @default.
• W3119300143 hasConcept C54355233 @default.
• W3119300143 hasConcept C71924100 @default.
• W3119300143 hasConcept C80227256 @default.
• W3119300143 hasConcept C86803240 @default.
• W3119300143 hasConceptScore W3119300143C104317684 @default.
• W3119300143 hasConceptScore W3119300143C126322002 @default.
• W3119300143 hasConceptScore W3119300143C131872663 @default.
• W3119300143 hasConceptScore W3119300143C167135981 @default.
• W3119300143 hasConceptScore W3119300143C172680121 @default.
• W3119300143 hasConceptScore W3119300143C2776210078 @default.
• W3119300143 hasConceptScore W3119300143C2776229224 @default.
• W3119300143 hasConceptScore W3119300143C2776352029 @default.
• W3119300143 hasConceptScore W3119300143C2778258057 @default.
• W3119300143 hasConceptScore W3119300143C2779142324 @default.
• W3119300143 hasConceptScore W3119300143C2779234561 @default.
• W3119300143 hasConceptScore W3119300143C2779672484 @default.

• next