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- W3119302080 abstract "We previously reported the usefulness of droplet digital polymerase chain reaction (ddPCR) for the assessment of Human epithelial growth factor receptor 2 (HER2) gene amplification in breast cancer using formalin-fixed and paraffin-embedded sections. In our previous study, we combined HER2/CEP17 ratio (HER2 gene signals to chromosome 17 signals) with ddPCR and tumor content ratio (TCR) of each sample and determined the HER2 status by adopting a two-dimensional chart. This ddPCR-TCR method showed a high concordance with conventional HER2 status. In this study, we updated our method to assess the HER2 status of breast cancer in a more quantitative manner. We combined obtained data of the ddPCR ratio [Rx ] and TCR [x]; we calculated (Rx - 1)/x + 1 for 41 samples with primary breast cancer and named the value led by this formula as eHER2 (estimated HER2/CEP17 ratio of a tumor cell). eHER2 was equivalent to conventional in situ hybridization (ISH) HER2/CEP17 ratio in most cases. eHER2 and ISH ratio showed a strong correlation (Spearman rank correlation ρ = 0.70, p < 0.0001). The obtained results indicated that eHER2 is a potential tool for HER2 status diagnosis in breast cancer." @default.
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- W3119302080 date "2021-07-21" @default.
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- W3119302080 title "Quantitative assessment of HER2 gene amplification of breast cancer using droplet digital PCR" @default.
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- W3119302080 doi "https://doi.org/10.1111/pin.13128" @default.
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