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• W3119302402 startingPage "2472" @default.
• W3119302402 abstract "Alginate solutions crosslink into microspheres in calcium alginate, enabling the encapsulation and subsequent release of biological macromolecules and drugs. However, release from calcium alginate into PBS is relatively fast because it will decrosslink the gel relatively quickly. In this research, FITC-dextran (MW 10 kDa) was encapsulated in 2% (w/v) calcium alginate microspheres by electrospraying. The resulting microspheres (diameter = 247 ± 13 μm) were then layered with thin polyelectrolyte films of hyaluronic acid (HA) and poly-l-lysine (PLL) to attempt to slow the diffusion of FITC-dextran out of the microspheres and the coating parameters were modified to modulate diffusion and release. Increasing the concentration of FITC-dextran encapsulated in the microspheres resulted in an increase in its release over time into PBS. Crosslinking PLL/HA layers on the microspheres did not decrease the in vitro release rates of encapsulated FITC-dextran into PBS. Increasing the number of layers on the microspheres from 3 to 5 layers significantly decreased the amount of encapsulated FITC-dextran released. However, increasing the number of layers to 7 did not further sustain the release of FITC-dextran, likely because these microspheres collapsed to a smaller size during the coating procedure, resulting in release controlled by both diffusion and swelling. Multiple layers of PLL and HA provided a robust mechanism to sustain and control release of large molecules from calcium alginate." @default.
• W3119302402 created "2021-01-18" @default.
• W3119302402 creator A5029859034 @default.
• W3119302402 creator A5088641134 @default.
• W3119302402 date "2021-06-01" @default.
• W3119302402 modified "2023-09-26" @default.
• W3119302402 title "Hyaluronic Acid and Poly-l-Lysine Layers on Calcium Alginate Microspheres to Modulate the Release of Encapsulated FITC-Dextran" @default.
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• W3119302402 doi "https://doi.org/10.1016/j.xphs.2021.01.006" @default.
• W3119302402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33450219" @default.
• W3119302402 hasPublicationYear "2021" @default.
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