FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119343341> ?p ?o ?g. }

• W3119343341 endingPage "353" @default.
• W3119343341 startingPage "353" @default.
• W3119343341 abstract "Nasopharyngeal swab nucleic acid amplification testing (NAAT) is the noninvasive criterion standard for diagnosis of coronavirus disease 2019 (COVID-19). However, it requires trained personnel, limiting its availability. Saliva NAAT represents an attractive alternative, but its diagnostic performance is unclear.To assess the diagnostic accuracy of saliva NAAT for COVID-19.In this systematic review, a search of the MEDLINE and medRxiv databases was conducted on August 29, 2020, to find studies of diagnostic test accuracy. The final meta-analysis was performed on November 17, 2020.Studies needed to provide enough data to measure salivary NAAT sensitivity and specificity compared with imperfect nasopharyngeal swab NAAT as a reference test. An imperfect reference test does not perfectly reflect the truth (ie, it can give false results). Studies were excluded if the sample contained fewer than 20 participants or was neither random nor consecutive. The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to assess the risk of bias.Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline was followed for the systematic review, with multiple authors involved at each stage of the review. To account for the imperfect reference test sensitivity, we used a bayesian latent class bivariate model for the meta-analysis.The primary outcome was pooled sensitivity and specificity. Two secondary analyses were performed: one restricted to peer-reviewed studies, and a post hoc analysis limited to ambulatory settings.The search strategy yielded 385 references, and 16 unique studies were identified for quantitative synthesis. Eight peer-reviewed studies and 8 preprints were included in the meta-analyses (5922 unique patients). There was significant variability in patient selection, study design, and stage of illness at which patients were enrolled. Fifteen studies included ambulatory patients, and 9 exclusively enrolled from an outpatient population with mild or no symptoms. In the primary analysis, the saliva NAAT pooled sensitivity was 83.2% (95% credible interval [CrI], 74.7%-91.4%) and the pooled specificity was 99.2% (95% CrI, 98.2%-99.8%). The nasopharyngeal swab NAAT had a sensitivity of 84.8% (95% CrI, 76.8%-92.4%) and a specificity of 98.9% (95% CrI, 97.4%-99.8%). Results were similar in secondary analyses.These results suggest that saliva NAAT diagnostic accuracy is similar to that of nasopharyngeal swab NAAT, especially in the ambulatory setting. These findings support larger-scale research on the use of saliva NAAT as an alternative to nasopharyngeal swabs." @default.
• W3119343341 created "2021-01-18" @default.
• W3119343341 creator A5008646749 @default.
• W3119343341 creator A5019497293 @default.
• W3119343341 creator A5040595008 @default.
• W3119343341 creator A5056802196 @default.
• W3119343341 creator A5061133637 @default.
• W3119343341 creator A5082630601 @default.
• W3119343341 creator A5088367550 @default.
• W3119343341 date "2021-03-01" @default.
• W3119343341 modified "2023-10-01" @default.
• W3119343341 title "Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2" @default.
• W3119343341 cites W1973914781 @default.
• W3119343341 cites W2023529456 @default.
• W3119343341 cites W2053709780 @default.
• W3119343341 cites W2107638293 @default.
• W3119343341 cites W2108868101 @default.
• W3119343341 cites W2117294447 @default.
• W3119343341 cites W2134833483 @default.
• W3119343341 cites W3005690553 @default.
• W3119343341 cites W3014463639 @default.
• W3119343341 cites W3017281285 @default.
• W3119343341 cites W3024499544 @default.
• W3119343341 cites W3025330863 @default.
• W3119343341 cites W3032373213 @default.
• W3119343341 cites W3033546757 @default.
• W3119343341 cites W3033718954 @default.
• W3119343341 cites W3035619009 @default.
• W3119343341 cites W3037756456 @default.
• W3119343341 cites W3038011122 @default.
• W3119343341 cites W3040696589 @default.
• W3119343341 cites W3044712404 @default.
• W3119343341 cites W3045507769 @default.
• W3119343341 cites W3045593206 @default.
• W3119343341 cites W3047145113 @default.
• W3119343341 cites W3048385964 @default.
• W3119343341 cites W3080652759 @default.
• W3119343341 cites W3083783694 @default.
• W3119343341 cites W3084544519 @default.
• W3119343341 cites W3091526083 @default.
• W3119343341 cites W4250000864 @default.
• W3119343341 doi "https://doi.org/10.1001/jamainternmed.2020.8876" @default.
• W3119343341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7811189" @default.
• W3119343341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33449069" @default.
• W3119343341 hasPublicationYear "2021" @default.
• W3119343341 type Work @default.
• W3119343341 sameAs 3119343341 @default.
• W3119343341 citedByCount "247" @default.
• W3119343341 countsByYear W31193433412020 @default.
• W3119343341 countsByYear W31193433412021 @default.
• W3119343341 countsByYear W31193433412022 @default.
• W3119343341 countsByYear W31193433412023 @default.
• W3119343341 crossrefType "journal-article" @default.
• W3119343341 hasAuthorship W3119343341A5008646749 @default.
• W3119343341 hasAuthorship W3119343341A5019497293 @default.
• W3119343341 hasAuthorship W3119343341A5040595008 @default.
• W3119343341 hasAuthorship W3119343341A5056802196 @default.
• W3119343341 hasAuthorship W3119343341A5061133637 @default.
• W3119343341 hasAuthorship W3119343341A5082630601 @default.
• W3119343341 hasAuthorship W3119343341A5088367550 @default.
• W3119343341 hasBestOaLocation W31193433411 @default.
• W3119343341 hasConcept C105795698 @default.
• W3119343341 hasConcept C126322002 @default.
• W3119343341 hasConcept C129848803 @default.
• W3119343341 hasConcept C159047783 @default.
• W3119343341 hasConcept C17744445 @default.
• W3119343341 hasConcept C199539241 @default.
• W3119343341 hasConcept C2777391075 @default.
• W3119343341 hasConcept C2779134260 @default.
• W3119343341 hasConcept C2779473830 @default.
• W3119343341 hasConcept C2909633786 @default.
• W3119343341 hasConcept C3008058167 @default.
• W3119343341 hasConcept C33923547 @default.
• W3119343341 hasConcept C524204448 @default.
• W3119343341 hasConcept C71924100 @default.
• W3119343341 hasConcept C95190672 @default.
• W3119343341 hasConceptScore W3119343341C105795698 @default.
• W3119343341 hasConceptScore W3119343341C126322002 @default.
• W3119343341 hasConceptScore W3119343341C129848803 @default.
• W3119343341 hasConceptScore W3119343341C159047783 @default.
• W3119343341 hasConceptScore W3119343341C17744445 @default.
• W3119343341 hasConceptScore W3119343341C199539241 @default.
• W3119343341 hasConceptScore W3119343341C2777391075 @default.
• W3119343341 hasConceptScore W3119343341C2779134260 @default.
• W3119343341 hasConceptScore W3119343341C2779473830 @default.
• W3119343341 hasConceptScore W3119343341C2909633786 @default.
• W3119343341 hasConceptScore W3119343341C3008058167 @default.
• W3119343341 hasConceptScore W3119343341C33923547 @default.
• W3119343341 hasConceptScore W3119343341C524204448 @default.
• W3119343341 hasConceptScore W3119343341C71924100 @default.
• W3119343341 hasConceptScore W3119343341C95190672 @default.
• W3119343341 hasIssue "3" @default.
• W3119343341 hasLocation W31193433411 @default.
• W3119343341 hasLocation W31193433412 @default.
• W3119343341 hasLocation W31193433413 @default.
• W3119343341 hasOpenAccess W3119343341 @default.
• W3119343341 hasPrimaryLocation W31193433411 @default.
• W3119343341 hasRelatedWork W1974975370 @default.

• next