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- W3119347788 abstract "In response to severe genetic and environmental perturbations, wild-type organisms can express hidden alternative phenotypes adaptive to such adverse conditions. While our theoretical understanding of the population-level fitness advantage and evolution of phenotypic switching under variable environments has grown, the mechanism by which these organisms maintain phenotypic switching capabilities under static environments remains to be elucidated. Here, using computational simulations, we analyzed the evolution of gene circuits under natural selection and found that different strategies evolved to increase the gene expression stability near the optimum level. In a population comprising bistable individuals, a strategy of maintaining bistability and raising the potential barrier separating the bistable regimes was consistently taken. Our results serve as evidence that hidden bistable switches can be stably maintained during environmental stasis—an essential property enabling the timely release of adaptive alternatives with small genetic changes in the event of substantial perturbations. Computational simulations show that selection for high gene expression stability can explain the stable maintenance of obsolete phenotypic switching capabilities under natural selection." @default.
- W3119347788 created "2021-01-18" @default.
- W3119347788 creator A5005997934 @default.
- W3119347788 creator A5009607229 @default.
- W3119347788 date "2021-01-14" @default.
- W3119347788 modified "2023-10-15" @default.
- W3119347788 title "Stable maintenance of hidden switches as a strategy to increase the gene expression stability" @default.
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- W3119347788 doi "https://doi.org/10.1038/s43588-020-00001-y" @default.
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