Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119367739> ?p ?o ?g. }
- W3119367739 abstract "Abstract Background HOMER family scaffolding proteins (HOMER1-3) play critical roles in the development and progression of human disease by regulating the assembly of signal transduction complexes in response to extrinsic stimuli. However, the role of HOMER protein in breast cancer remains unclear. Methods HOMER3 expression was examined by immunohistochemistry in breast cancer patient specimens, and its significance in prognosis was assessed by Kaplan–Meier survival analysis. The effects of HOMER3 in growth factor-induced β-Catenin activation were analyzed by assays such as TOP/FOP flash reporter, tyrosine phosphorylation assay and reciprocal immunoprecipitation (IP) assay. Role of HOMER3 in breast cancer metastasis was determined by cell function assays and mice tumor models. Results Herein, we find that, among the three HOMER proteins, HOMER3 is selectively overexpressed in the most aggressive triple negative breast cancer (TNBC) subtype, and significantly correlates with earlier tumor metastasis and shorter patient survival. Mechanismly, HOMER3 interacts with both c-Src and β-Catenin, thus providing a scaffolding platform to facilitate c-Src-induced β-Catenin tyrosine phosphorylation under growth factor stimulation. HOMER3 promotes β-Catenin nuclear translocation and activation, and this axis is clinically relevant. HOMER3 promotes and is essential for EGF-induced aggressiveness and metastasis of TNBC cells both in vitro and in vivo. Conclusion These findings identify a novel role of HOMER3 in the transduction of growth factor-mediated β-Catenin activation and suggest that HOMER3 might be a targetable vulnerability of TNBC." @default.
- W3119367739 created "2021-01-18" @default.
- W3119367739 creator A5011659627 @default.
- W3119367739 creator A5012443982 @default.
- W3119367739 creator A5017543453 @default.
- W3119367739 creator A5018141029 @default.
- W3119367739 creator A5045549222 @default.
- W3119367739 creator A5052944511 @default.
- W3119367739 creator A5060177975 @default.
- W3119367739 creator A5065502799 @default.
- W3119367739 creator A5068289835 @default.
- W3119367739 creator A5068540093 @default.
- W3119367739 creator A5075049296 @default.
- W3119367739 creator A5077068949 @default.
- W3119367739 creator A5077120359 @default.
- W3119367739 creator A5085993678 @default.
- W3119367739 creator A5087269163 @default.
- W3119367739 date "2021-01-06" @default.
- W3119367739 modified "2023-10-17" @default.
- W3119367739 title "HOMER3 facilitates growth factor-mediated β-Catenin tyrosine phosphorylation and activation to promote metastasis in triple negative breast cancer" @default.
- W3119367739 cites W1073664769 @default.
- W3119367739 cites W1557400022 @default.
- W3119367739 cites W1592873778 @default.
- W3119367739 cites W1878739498 @default.
- W3119367739 cites W1976982332 @default.
- W3119367739 cites W1977193949 @default.
- W3119367739 cites W2020392597 @default.
- W3119367739 cites W2030350068 @default.
- W3119367739 cites W2042651745 @default.
- W3119367739 cites W2050328564 @default.
- W3119367739 cites W2062904839 @default.
- W3119367739 cites W2064126710 @default.
- W3119367739 cites W2071421185 @default.
- W3119367739 cites W2073759231 @default.
- W3119367739 cites W2076931029 @default.
- W3119367739 cites W2079207159 @default.
- W3119367739 cites W2085368051 @default.
- W3119367739 cites W2096027508 @default.
- W3119367739 cites W2096283457 @default.
- W3119367739 cites W2102424174 @default.
- W3119367739 cites W2106204137 @default.
- W3119367739 cites W2117421244 @default.
- W3119367739 cites W2162708312 @default.
- W3119367739 cites W2165936545 @default.
- W3119367739 cites W2228127492 @default.
- W3119367739 cites W2278176497 @default.
- W3119367739 cites W2482864649 @default.
- W3119367739 cites W2604936036 @default.
- W3119367739 cites W2621361823 @default.
- W3119367739 cites W2756148605 @default.
- W3119367739 cites W2762027402 @default.
- W3119367739 cites W2790916173 @default.
- W3119367739 cites W2889646458 @default.
- W3119367739 cites W2895079804 @default.
- W3119367739 cites W3005975381 @default.
- W3119367739 cites W80971072 @default.
- W3119367739 doi "https://doi.org/10.1186/s13045-020-01021-x" @default.
- W3119367739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7788750" @default.
- W3119367739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33407765" @default.
- W3119367739 hasPublicationYear "2021" @default.
- W3119367739 type Work @default.
- W3119367739 sameAs 3119367739 @default.
- W3119367739 citedByCount "9" @default.
- W3119367739 countsByYear W31193677392021 @default.
- W3119367739 countsByYear W31193677392022 @default.
- W3119367739 countsByYear W31193677392023 @default.
- W3119367739 crossrefType "journal-article" @default.
- W3119367739 hasAuthorship W3119367739A5011659627 @default.
- W3119367739 hasAuthorship W3119367739A5012443982 @default.
- W3119367739 hasAuthorship W3119367739A5017543453 @default.
- W3119367739 hasAuthorship W3119367739A5018141029 @default.
- W3119367739 hasAuthorship W3119367739A5045549222 @default.
- W3119367739 hasAuthorship W3119367739A5052944511 @default.
- W3119367739 hasAuthorship W3119367739A5060177975 @default.
- W3119367739 hasAuthorship W3119367739A5065502799 @default.
- W3119367739 hasAuthorship W3119367739A5068289835 @default.
- W3119367739 hasAuthorship W3119367739A5068540093 @default.
- W3119367739 hasAuthorship W3119367739A5075049296 @default.
- W3119367739 hasAuthorship W3119367739A5077068949 @default.
- W3119367739 hasAuthorship W3119367739A5077120359 @default.
- W3119367739 hasAuthorship W3119367739A5085993678 @default.
- W3119367739 hasAuthorship W3119367739A5087269163 @default.
- W3119367739 hasBestOaLocation W31193677391 @default.
- W3119367739 hasConcept C11960822 @default.
- W3119367739 hasConcept C121608353 @default.
- W3119367739 hasConcept C126322002 @default.
- W3119367739 hasConcept C137620995 @default.
- W3119367739 hasConcept C2777553839 @default.
- W3119367739 hasConcept C2779013556 @default.
- W3119367739 hasConcept C2780110267 @default.
- W3119367739 hasConcept C30145163 @default.
- W3119367739 hasConcept C502942594 @default.
- W3119367739 hasConcept C530470458 @default.
- W3119367739 hasConcept C62478195 @default.
- W3119367739 hasConcept C71924100 @default.
- W3119367739 hasConcept C86803240 @default.
- W3119367739 hasConcept C95444343 @default.
- W3119367739 hasConceptScore W3119367739C11960822 @default.
- W3119367739 hasConceptScore W3119367739C121608353 @default.
- W3119367739 hasConceptScore W3119367739C126322002 @default.