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- W3119369275 abstract "Gene variants provide the raw material for natural selection and are the foundation for physiological resilience in all species. Understanding the genetic basis for traits facing intensified selection from climate change is a crucial step in developing effective conservation and restoration initiatives. This is particularly true for reef-building corals, which are among the most vulnerable to global climate change and that are in dramatic decline globally. At the Rowley Shoals in Western Australia, the prominent reef flat becomes exposed on low tide and the stagnant water in the shallow atoll lagoons heats up, creating a natural laboratory for characterising allele frequencies that control phenotypic responses to different environments. We used full genome low-coverage (~4x) re-sequencing to search for signatures of selection in the reef-building coral Acropora tenuis to this warm lagoon habitat. We collected tissue samples from coral colonies from both lagoon and adjacent reef slope habitats and calculated genotype likelihoods across 6.5M variant sites without hard-calling genotypes. Our data show that despite high gene flow between habitats, spatially varying selection drives subtle shifts in allele frequencies at hundreds of loci. Loci showing strong signs of selection to the lagoon were concentrated on a single chromosomal region of approximately 40 kb in size, showed strong signs of linkage disequilibrium, and spanned genes with homology to proteins involved in cell signalling and immunity. Across this genomic island of divergence, we identified strong linkage among SNPs and a coordinated increase in minor allele frequencies in corals taken from the lagoon habitat, where the range of environmental conditions is greatest. Interestingly, the site frequency spectrum in corals from the reef slope was dominated by moderate frequency alleles, suggesting that balancing selection may be maintaining alleles at higher frequencies in the broader metapopulation. The identification of a group of candidate loci in corals that confer resilience to environmental stressors showcases the utility of low-coverage sequencing approaches for dissecting complex climate-related traits, and advances our understanding of the molecular and physiological systems that will enable coral survival through climate change." @default.
- W3119369275 created "2021-01-18" @default.
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- W3119369275 date "2020-12-22" @default.
- W3119369275 modified "2023-10-08" @default.
- W3119369275 title "Subtle Allele Frequency Shifts Drive Climate Adaptation in Reef Coral of Northwest Australia" @default.
- W3119369275 hasPublicationYear "2020" @default.
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