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• W3119372191 endingPage "723" @default.
• W3119372191 startingPage "719" @default.
• W3119372191 abstract "O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (i.e., O-GlcNAcylation) on the serine/threonine residues of proteins. As a unique intracellular monosaccharide modification, protein O-GlcNAcylation plays important roles in almost all biochemical processes examined. Aberrant O-GlcNAcylation underlies the etiologies of a number of chronic diseases. With the tremendous improvement of techniques, thousands of proteins along with their O-GlcNAc sites have been reported. However, until now, there are few databases dedicated to accommodate the rapid accumulation of such information. Thus, O-GlcNAcAtlas is created to integrate all experimentally identified O-GlcNAc sites and proteins. O-GlcNAcAtlas consists of two datasets (Dataset-I and Dataset-II, for unambiguously identified sites and ambiguously identified sites, respectively), representing a total number of 4571 O-GlcNAc modified proteins from all species studied from 1984 to 31 Dec 2019. For each protein, comprehensive information (including species, sample type, gene symbol, modified peptides and/or modification sites, site mapping methods and literature references) is provided. To solve the heterogeneity among the data collected from different sources, the sequence identity of these reported O-GlcNAc peptides are mapped to the UniProtKB protein entries. To our knowledge, O-GlcNAcAtlas is a highly comprehensive and rigorously curated database encapsulating all O-GlcNAc sites and proteins identified in the past 35 years. We expect that O-GlcNAcAtlas will be a useful resource to facilitate O-GlcNAc studies and computational analyses of protein O-GlcNAcylation. The public version of the web interface to the O-GlcNAcAtlas can be found at http://oglcnac.org/." @default.
• W3119372191 created "2021-01-18" @default.
• W3119372191 creator A5003348501 @default.
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• W3119372191 date "2021-01-12" @default.
• W3119372191 modified "2023-10-14" @default.
• W3119372191 title "O-GlcNAcAtlas: A database of experimentally identified O-GlcNAc sites and proteins" @default.
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• W3119372191 doi "https://doi.org/10.1093/glycob/cwab003" @default.
• W3119372191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8351508" @default.
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• W3119372191 hasPublicationYear "2021" @default.
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