FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119383380> ?p ?o ?g. }

• W3119383380 endingPage "108" @default.
• W3119383380 startingPage "101" @default.
• W3119383380 abstract "This study investigated the risk of congenital heart defects (CHD) and other congenital anomalies (CA) associated with first trimester use of macrolide antibiotics (mainly erythromycin, spiramycin, clarithromycin and azithromycin) and lincosamides (clindamycin) using a case-malformed control design. Data included 145,936 babies with a CA diagnosis (livebirths, stillbirths and terminations of pregnancy for CA) from 15 population-based EUROCAT registries in 13 European countries, covering 9 million births 1995–2012. Cases were babies with CHD, anencephaly, orofacial clefts, genital and limb reduction anomalies associated with antibiotic exposure in the literature. Controls were babies with other CA or genetic conditions. Main outcomes were odds ratios adjusted (AOR) for maternal age and registry, with 95 % Confidence Intervals (95 %CI). Macrolide and lincosamide exposure was recorded for 307 and 28 cases, 72 and 4 non-genetic controls, 57 and 7 genetic controls, respectively. AOR for CHD was not significantly raised (AOR 0.94, 95 %CI: 0.70–1.26 vs non-genetic controls; AOR 1.01, 95 %CI: 0.73–1.41 vs genetic controls), nor significantly raised for any specific macrolide. The risk of atrioventricular septal defect was significantly raised with exposure to any macrolide (AOR 2.98; 95 %CI: 1.48–6.01), erythromycin (AOR 3.68, 95 %CI: 1.28–10.61), and azithromycin (AOR 4.50, 95 %CI: 1.30–15.58). Erythromycin, clarithromycin, azithromycin, and clindamycin were associated with an increased risk of at least one other CA. Further research is needed on the risk of specific CA associated with macrolide and lincosamide use in the first trimester, particularly relevant for the potential use of azithromycin in the treatment of COVID-19." @default.
• W3119383380 created "2021-01-18" @default.
• W3119383380 creator A5006449900 @default.
• W3119383380 creator A5011696603 @default.
• W3119383380 creator A5016198352 @default.
• W3119383380 creator A5017201667 @default.
• W3119383380 creator A5019449110 @default.
• W3119383380 creator A5027140413 @default.
• W3119383380 creator A5032293864 @default.
• W3119383380 creator A5042778415 @default.
• W3119383380 creator A5044231230 @default.
• W3119383380 creator A5044712331 @default.
• W3119383380 creator A5046426052 @default.
• W3119383380 creator A5050773090 @default.
• W3119383380 creator A5065651886 @default.
• W3119383380 creator A5068452281 @default.
• W3119383380 creator A5068802182 @default.
• W3119383380 creator A5072128652 @default.
• W3119383380 creator A5084306497 @default.
• W3119383380 creator A5086996566 @default.
• W3119383380 date "2021-03-01" @default.
• W3119383380 modified "2023-10-02" @default.
• W3119383380 title "Macrolide and lincosamide antibiotic exposure in the first trimester of pregnancy and risk of congenital anomaly: A European case-control study" @default.
• W3119383380 cites W1555156942 @default.
• W3119383380 cites W1861816252 @default.
• W3119383380 cites W1910596231 @default.
• W3119383380 cites W1960140973 @default.
• W3119383380 cites W1964502765 @default.
• W3119383380 cites W1979705549 @default.
• W3119383380 cites W1986992157 @default.
• W3119383380 cites W1987454106 @default.
• W3119383380 cites W2002688001 @default.
• W3119383380 cites W2010011956 @default.
• W3119383380 cites W2018225521 @default.
• W3119383380 cites W2021087453 @default.
• W3119383380 cites W2034182983 @default.
• W3119383380 cites W2038090062 @default.
• W3119383380 cites W2039814494 @default.
• W3119383380 cites W2048937347 @default.
• W3119383380 cites W2055786645 @default.
• W3119383380 cites W2057074470 @default.
• W3119383380 cites W2058407846 @default.
• W3119383380 cites W2079364967 @default.
• W3119383380 cites W2092275408 @default.
• W3119383380 cites W2116953657 @default.
• W3119383380 cites W2129229777 @default.
• W3119383380 cites W2141172232 @default.
• W3119383380 cites W2145771428 @default.
• W3119383380 cites W2145891230 @default.
• W3119383380 cites W2150557024 @default.
• W3119383380 cites W2155741281 @default.
• W3119383380 cites W2160405047 @default.
• W3119383380 cites W2189204398 @default.
• W3119383380 cites W2473104846 @default.
• W3119383380 cites W2738111436 @default.
• W3119383380 cites W2795805681 @default.
• W3119383380 cites W2799522502 @default.
• W3119383380 cites W2955688011 @default.
• W3119383380 cites W3006784812 @default.
• W3119383380 doi "https://doi.org/10.1016/j.reprotox.2021.01.006" @default.
• W3119383380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33454317" @default.
• W3119383380 hasPublicationYear "2021" @default.
• W3119383380 type Work @default.
• W3119383380 sameAs 3119383380 @default.
• W3119383380 citedByCount "7" @default.
• W3119383380 countsByYear W31193833802021 @default.
• W3119383380 countsByYear W31193833802022 @default.
• W3119383380 countsByYear W31193833802023 @default.
• W3119383380 crossrefType "journal-article" @default.
• W3119383380 hasAuthorship W3119383380A5006449900 @default.
• W3119383380 hasAuthorship W3119383380A5011696603 @default.
• W3119383380 hasAuthorship W3119383380A5016198352 @default.
• W3119383380 hasAuthorship W3119383380A5017201667 @default.
• W3119383380 hasAuthorship W3119383380A5019449110 @default.
• W3119383380 hasAuthorship W3119383380A5027140413 @default.
• W3119383380 hasAuthorship W3119383380A5032293864 @default.
• W3119383380 hasAuthorship W3119383380A5042778415 @default.
• W3119383380 hasAuthorship W3119383380A5044231230 @default.
• W3119383380 hasAuthorship W3119383380A5044712331 @default.
• W3119383380 hasAuthorship W3119383380A5046426052 @default.
• W3119383380 hasAuthorship W3119383380A5050773090 @default.
• W3119383380 hasAuthorship W3119383380A5065651886 @default.
• W3119383380 hasAuthorship W3119383380A5068452281 @default.
• W3119383380 hasAuthorship W3119383380A5068802182 @default.
• W3119383380 hasAuthorship W3119383380A5072128652 @default.
• W3119383380 hasAuthorship W3119383380A5084306497 @default.
• W3119383380 hasAuthorship W3119383380A5086996566 @default.
• W3119383380 hasBestOaLocation W31193833802 @default.
• W3119383380 hasConcept C126322002 @default.
• W3119383380 hasConcept C131872663 @default.
• W3119383380 hasConcept C146304588 @default.
• W3119383380 hasConcept C156957248 @default.
• W3119383380 hasConcept C187212893 @default.
• W3119383380 hasConcept C2776409635 @default.
• W3119383380 hasConcept C2776962512 @default.
• W3119383380 hasConcept C2777458120 @default.
• W3119383380 hasConcept C2778907293 @default.
• W3119383380 hasConcept C2779172262 @default.

• next