FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119406563> ?p ?o ?g. }

• W3119406563 endingPage "116460" @default.
• W3119406563 startingPage "116460" @default.
• W3119406563 abstract "Both legacy and emerging per- and polyfluoroalkyl substances (PFAS) have been found to be threats to human health. In particular, fetuses are sensitive to xenobiotics and the placenta functions as a significant barrier for environmental pollutants. The placental transfer of PFAS is closely related to their interactions with proteins. In this study, 54 human placental samples were collected to investigate the occurrence of legacy and emerging PFAS in human placenta, including perfluorinated carboxylates (PFCAs), perfluorinated sulfonates (PFSAs), chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs), and fluorotelomer sulfonates (FTSAs). Among the legacy PFAS, perfluorooctanesulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were detected in all samples, with PFOS and PFOA being the two predominant (mean: 0.457 and 0.242 ng/g wet weight, respectively). Among the emerging PFAS, 6:2 Cl-PFESA was detected in all samples with the mean value of 0.104 ng/g wet weight, while the detect frequency (DF) of 8:2 Cl-PFESAs was only 24%. The concentration and DF of the four FTSA congeners were low in the placentas. Molecular docking calculation results showed that the binding affinities of PFAS to the human serum albumin (HSA) were increased with chain length in each category except for the PFCAs, of which the perfluoroundecanoic acid (PFUnDA) was the turning point of binding affinity to HSA. For PFSAs, their binding affinities to organic anion transporter 4 (OAT4) were increased with the chain length except for the sodium perfluoro-1-heptanesulfonate (PFHpS) and sodium perfluoro-1-nonanesulfonate (PFNS). The calculation results demonstrated that the placental transfer of PFAS is closely related to chain length. The findings in the study can help better understand the occurrence of the PFAS in the human placenta and the placental transfer mechanisms of PFAS in human beings." @default.
• W3119406563 created "2021-01-18" @default.
• W3119406563 creator A5020576909 @default.
• W3119406563 creator A5052126630 @default.
• W3119406563 creator A5056025604 @default.
• W3119406563 creator A5058394999 @default.
• W3119406563 creator A5068875986 @default.
• W3119406563 creator A5072379029 @default.
• W3119406563 creator A5078915518 @default.
• W3119406563 creator A5091410060 @default.
• W3119406563 date "2021-03-01" @default.
• W3119406563 modified "2023-10-17" @default.
• W3119406563 title "The occurrence of PFAS in human placenta and their binding abilities to human serum albumin and organic anion transporter 4" @default.
• W3119406563 cites W1841600388 @default.
• W3119406563 cites W1970016764 @default.
• W3119406563 cites W1982257539 @default.
• W3119406563 cites W2003476857 @default.
• W3119406563 cites W2033438697 @default.
• W3119406563 cites W2043672781 @default.
• W3119406563 cites W2061745280 @default.
• W3119406563 cites W2074986801 @default.
• W3119406563 cites W2110453474 @default.
• W3119406563 cites W2115616473 @default.
• W3119406563 cites W2121208009 @default.
• W3119406563 cites W2123206621 @default.
• W3119406563 cites W2198432873 @default.
• W3119406563 cites W2560702716 @default.
• W3119406563 cites W2589816650 @default.
• W3119406563 cites W2598111220 @default.
• W3119406563 cites W2606422217 @default.
• W3119406563 cites W2609362960 @default.
• W3119406563 cites W2612242140 @default.
• W3119406563 cites W2612263559 @default.
• W3119406563 cites W2750612244 @default.
• W3119406563 cites W2761909585 @default.
• W3119406563 cites W2771977965 @default.
• W3119406563 cites W2801972320 @default.
• W3119406563 cites W2894219029 @default.
• W3119406563 cites W2909504601 @default.
• W3119406563 cites W2913583726 @default.
• W3119406563 cites W2913899896 @default.
• W3119406563 cites W2914193584 @default.
• W3119406563 cites W2944857720 @default.
• W3119406563 cites W2954870180 @default.
• W3119406563 cites W2974156380 @default.
• W3119406563 cites W2992604222 @default.
• W3119406563 cites W3016124517 @default.
• W3119406563 cites W3028932722 @default.
• W3119406563 doi "https://doi.org/10.1016/j.envpol.2021.116460" @default.
• W3119406563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33485002" @default.
• W3119406563 hasPublicationYear "2021" @default.
• W3119406563 type Work @default.
• W3119406563 sameAs 3119406563 @default.
• W3119406563 citedByCount "46" @default.
• W3119406563 countsByYear W31194065632021 @default.
• W3119406563 countsByYear W31194065632022 @default.
• W3119406563 countsByYear W31194065632023 @default.
• W3119406563 crossrefType "journal-article" @default.
• W3119406563 hasAuthorship W3119406563A5020576909 @default.
• W3119406563 hasAuthorship W3119406563A5052126630 @default.
• W3119406563 hasAuthorship W3119406563A5056025604 @default.
• W3119406563 hasAuthorship W3119406563A5058394999 @default.
• W3119406563 hasAuthorship W3119406563A5068875986 @default.
• W3119406563 hasAuthorship W3119406563A5072379029 @default.
• W3119406563 hasAuthorship W3119406563A5078915518 @default.
• W3119406563 hasAuthorship W3119406563A5091410060 @default.
• W3119406563 hasConcept C104317684 @default.
• W3119406563 hasConcept C107872376 @default.
• W3119406563 hasConcept C149011108 @default.
• W3119406563 hasConcept C172680121 @default.
• W3119406563 hasConcept C178790620 @default.
• W3119406563 hasConcept C185592680 @default.
• W3119406563 hasConcept C2775979320 @default.
• W3119406563 hasConcept C2776953305 @default.
• W3119406563 hasConcept C2778597219 @default.
• W3119406563 hasConcept C2779234561 @default.
• W3119406563 hasConcept C43617362 @default.
• W3119406563 hasConcept C537181965 @default.
• W3119406563 hasConcept C54355233 @default.
• W3119406563 hasConcept C55493867 @default.
• W3119406563 hasConcept C86803240 @default.
• W3119406563 hasConceptScore W3119406563C104317684 @default.
• W3119406563 hasConceptScore W3119406563C107872376 @default.
• W3119406563 hasConceptScore W3119406563C149011108 @default.
• W3119406563 hasConceptScore W3119406563C172680121 @default.
• W3119406563 hasConceptScore W3119406563C178790620 @default.
• W3119406563 hasConceptScore W3119406563C185592680 @default.
• W3119406563 hasConceptScore W3119406563C2775979320 @default.
• W3119406563 hasConceptScore W3119406563C2776953305 @default.
• W3119406563 hasConceptScore W3119406563C2778597219 @default.
• W3119406563 hasConceptScore W3119406563C2779234561 @default.
• W3119406563 hasConceptScore W3119406563C43617362 @default.
• W3119406563 hasConceptScore W3119406563C537181965 @default.
• W3119406563 hasConceptScore W3119406563C54355233 @default.
• W3119406563 hasConceptScore W3119406563C55493867 @default.
• W3119406563 hasConceptScore W3119406563C86803240 @default.
• W3119406563 hasFunder F4320321001 @default.
• W3119406563 hasLocation W31194065631 @default.

• next