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• W3119408043 endingPage "33" @default.
• W3119408043 startingPage "18" @default.
• W3119408043 abstract "Immunotherapy to treat cancer is now an established clinical approach. Immunotherapy can be applied systemically, as done with checkpoint blockade antibodies, but it can also be injected directly into identified tumors, in a strategy of in situ vaccination (ISV). ISV is designed to stimulate a strong local antitumor immune response involving both innate and adaptive immune cells, and through this generate a systemic antitumor immune response against metastatic tumors. A variety of ISVs have been utilized to generate an immunostimulatory tumor microenvironment (TME). These include attenuated microorganisms, recombinant proteins, small molecules, physical disruptors of TME (alternating magnetic and focused ultrasound heating, photothermal therapy, and radiotherapy), and more recently nanoparticles (NPs). NPs are attractive and unique since they can load multiple drugs or other reagents to influence immune and cancer cell functions in the TME, affording a unique opportunity to stimulate antitumor immunity. Here, we describe the NP-ISV therapeutic mechanisms, review chemically synthesized NPs (i.e., liposomes, polymeric, chitosan-based, inorganic NPs, etc.), biologically derived NPs (virus and bacteria-based NPs), and energy-activated NP-ISVs in the context of their use as local ISV. Data suggests that NP-ISVs can enhance outcomes of immunotherapeutic regimens including those utilizing tumor hyperthermia and checkpoint blockade therapies." @default.
• W3119408043 created "2021-01-18" @default.
• W3119408043 creator A5019451091 @default.
• W3119408043 creator A5027965992 @default.
• W3119408043 creator A5052623189 @default.
• W3119408043 creator A5071424591 @default.
• W3119408043 creator A5079851122 @default.
• W3119408043 date "2020-12-15" @default.
• W3119408043 modified "2023-09-30" @default.
• W3119408043 title "Using nanoparticles for<i>in situ</i>vaccination against cancer: mechanisms and immunotherapy benefits" @default.
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