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- W3119408919 abstract "Abstract Nuclear Argonaute proteins, guided to nascent target RNAs by their bound small RNAs, elicit co-transcriptional silencing through heterochromatin formation at transposon insertions and repetitive genomic loci. The molecular mechanisms involved in this process are incompletely understood. Here, we propose that the SFiNX complex, a silencing mediator downstream of nuclear Piwi-piRNA complexes in Drosophila , enables co-transcriptional silencing via the formation of molecular condensates. Condensate formation is stimulated by nucleic acid binding and requires SFiNX dimerization, mediated by the dynein light chain protein, LC8/Cutup. LC8’s function within SFiNX can be bypassed with a heterologous dimerization domain, suggesting that dimerization is a constitutive feature of SFiNX. Mutations preventing LC8-mediated SFiNX dimerization result in loss of condensate formation in vitro and inability of Piwi to initiate heterochromatin formation and silence transposons in vivo . Formation of molecular condensates might be a general mechanism that underlies effective heterochromatin establishment at small RNA target loci in a co-transcriptional manner." @default.
- W3119408919 created "2021-01-18" @default.
- W3119408919 creator A5003197618 @default.
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- W3119408919 creator A5077706769 @default.
- W3119408919 creator A5079430205 @default.
- W3119408919 date "2021-01-08" @default.
- W3119408919 modified "2023-10-16" @default.
- W3119408919 title "The molecular principles of Piwi-mediated co-transcriptional silencing through the dimeric SFiNX complex" @default.
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