Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119411632> ?p ?o ?g. }
- W3119411632 abstract "Abstract Chiral acetylenic derivatives are found in many bioactive compounds and are versatile functional groups in organic chemistry. Here, we describe an enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction from simple achiral materials under mild condition. The introduction of a Lewis acid cocatalyst is crucial to the efficiency of the transformation. Notably, we investigate this asymmetric propargylic substitution reaction for the development of a range of structurally diverse natural products. The power of this strategy is highlighted by the collective synthesis of seven biologically active compounds: (−)-Thiohexital, (+)-Thiopental, (+)-Pentobarbital, (−)-AMG 837, (+)-Phenoxanol, (+)-Citralis, and (−)-Citralis Nitrile." @default.
- W3119411632 created "2021-01-18" @default.
- W3119411632 creator A5012116144 @default.
- W3119411632 creator A5020545336 @default.
- W3119411632 creator A5031178920 @default.
- W3119411632 creator A5054419328 @default.
- W3119411632 date "2021-01-12" @default.
- W3119411632 modified "2023-10-18" @default.
- W3119411632 title "Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation" @default.
- W3119411632 cites W1861058787 @default.
- W3119411632 cites W1966912785 @default.
- W3119411632 cites W1967782701 @default.
- W3119411632 cites W1975785004 @default.
- W3119411632 cites W1976580344 @default.
- W3119411632 cites W1982479167 @default.
- W3119411632 cites W1998761932 @default.
- W3119411632 cites W2008224646 @default.
- W3119411632 cites W2041257786 @default.
- W3119411632 cites W2058217150 @default.
- W3119411632 cites W2072591300 @default.
- W3119411632 cites W2086488914 @default.
- W3119411632 cites W2087046315 @default.
- W3119411632 cites W2092356369 @default.
- W3119411632 cites W2111035444 @default.
- W3119411632 cites W2111833731 @default.
- W3119411632 cites W2121313057 @default.
- W3119411632 cites W2125106638 @default.
- W3119411632 cites W2128580220 @default.
- W3119411632 cites W2135346135 @default.
- W3119411632 cites W2140940325 @default.
- W3119411632 cites W2144257013 @default.
- W3119411632 cites W2274323975 @default.
- W3119411632 cites W2277980090 @default.
- W3119411632 cites W2293458570 @default.
- W3119411632 cites W2312853724 @default.
- W3119411632 cites W2421050621 @default.
- W3119411632 cites W2513976098 @default.
- W3119411632 cites W2544838710 @default.
- W3119411632 cites W2599270336 @default.
- W3119411632 cites W2604611986 @default.
- W3119411632 cites W2736511147 @default.
- W3119411632 cites W2763671613 @default.
- W3119411632 cites W2770027657 @default.
- W3119411632 cites W2789396021 @default.
- W3119411632 cites W2889973030 @default.
- W3119411632 cites W2890886050 @default.
- W3119411632 cites W2933240131 @default.
- W3119411632 cites W2949873895 @default.
- W3119411632 cites W3003901287 @default.
- W3119411632 cites W3007278934 @default.
- W3119411632 cites W3025385705 @default.
- W3119411632 cites W3029606208 @default.
- W3119411632 cites W4243470818 @default.
- W3119411632 doi "https://doi.org/10.1038/s41467-020-20644-9" @default.
- W3119411632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7803749" @default.
- W3119411632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33436637" @default.
- W3119411632 hasPublicationYear "2021" @default.
- W3119411632 type Work @default.
- W3119411632 sameAs 3119411632 @default.
- W3119411632 citedByCount "24" @default.
- W3119411632 countsByYear W31194116322021 @default.
- W3119411632 countsByYear W31194116322022 @default.
- W3119411632 countsByYear W31194116322023 @default.
- W3119411632 crossrefType "journal-article" @default.
- W3119411632 hasAuthorship W3119411632A5012116144 @default.
- W3119411632 hasAuthorship W3119411632A5020545336 @default.
- W3119411632 hasAuthorship W3119411632A5031178920 @default.
- W3119411632 hasAuthorship W3119411632A5054419328 @default.
- W3119411632 hasBestOaLocation W31194116321 @default.
- W3119411632 hasConcept C146686406 @default.
- W3119411632 hasConcept C161790260 @default.
- W3119411632 hasConcept C163638829 @default.
- W3119411632 hasConcept C164361826 @default.
- W3119411632 hasConcept C178790620 @default.
- W3119411632 hasConcept C185592680 @default.
- W3119411632 hasConcept C21951064 @default.
- W3119411632 hasConcept C2779240715 @default.
- W3119411632 hasConcept C535685238 @default.
- W3119411632 hasConceptScore W3119411632C146686406 @default.
- W3119411632 hasConceptScore W3119411632C161790260 @default.
- W3119411632 hasConceptScore W3119411632C163638829 @default.
- W3119411632 hasConceptScore W3119411632C164361826 @default.
- W3119411632 hasConceptScore W3119411632C178790620 @default.
- W3119411632 hasConceptScore W3119411632C185592680 @default.
- W3119411632 hasConceptScore W3119411632C21951064 @default.
- W3119411632 hasConceptScore W3119411632C2779240715 @default.
- W3119411632 hasConceptScore W3119411632C535685238 @default.
- W3119411632 hasFunder F4320321001 @default.
- W3119411632 hasIssue "1" @default.
- W3119411632 hasLocation W31194116321 @default.
- W3119411632 hasLocation W31194116322 @default.
- W3119411632 hasLocation W31194116323 @default.
- W3119411632 hasOpenAccess W3119411632 @default.
- W3119411632 hasPrimaryLocation W31194116321 @default.
- W3119411632 hasRelatedWork W2003757871 @default.
- W3119411632 hasRelatedWork W2019919093 @default.
- W3119411632 hasRelatedWork W2051822378 @default.
- W3119411632 hasRelatedWork W2064228317 @default.
- W3119411632 hasRelatedWork W2105226951 @default.
- W3119411632 hasRelatedWork W2588338208 @default.