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• W3119431323 abstract "Background: Drug loaded β-cyclodextrin based nanosponges (CDNS) are of special interest for the entrapment of moieties with the view to address their physicochemical challenges, and to improve their delivery characteristics and utility. Dithranol (DTH), the standard drug for psoriasis, has poor stability and solubility, which limit its pharmaceutical applications. Objective: The objective of the current study was to entrap DTH in CDNS in order to alleviate the above-mentioned challenges. Methods: To synthesize CDNS, β-cyclodextrin was treated with diphenyl carbonate in various molar ratios. The obtained placebo CDNS were loaded with DTH by lyophilisation. The particle size of the DTH loaded CDNS was found to lie between 150 and 450 nm, with a narrow polydispersity index range. Fourier transform infrared spectroscopy, thermal analysis, X-ray diffraction, zeta potential and electron microscopy with energy dispersive spectroscopy (EDS) were conducted for characterization of DTH-CDNS. Results: Findings from spectral examinations confirmed the formation of inclusion complexes. Solubilisation efficiency of DTH (in distilled water) was found augmented 4.54 folds with optimized CDNS. The cytocompatibility study was performed by the MTT assay employing THP1 cell lines. A remarkable amelioration in stability and photostability of DTH was also observed by its inclusion in nanosponges. Conclusion: In a nutshell, we report the rational engineering and characterization of DTH loaded cyclodextrin-based nanosponges, and subsequently, their stepwise screening for photostability, in vitro release, in vitro cytocompatibility, in vitro antioxidant and in vitro inflammatory activity in a top-down manner, yielding the best carrier for this drug." @default.
• W3119431323 created "2021-01-18" @default.
• W3119431323 creator A5033844142 @default.
• W3119431323 creator A5062391025 @default.
• W3119431323 date "2021-09-01" @default.
• W3119431323 modified "2023-09-26" @default.
• W3119431323 title "Novel Dithranol Loaded Cyclodextrin Nanosponges for Augmentation of Solubility, Photostability and Cytocompatibility" @default.
• W3119431323 cites W1266074700 @default.
• W3119431323 cites W1964227256 @default.
• W3119431323 cites W1965878073 @default.
• W3119431323 cites W1975586699 @default.
• W3119431323 cites W1985516105 @default.
• W3119431323 cites W1987708542 @default.
• W3119431323 cites W1990552784 @default.
• W3119431323 cites W2007542014 @default.
• W3119431323 cites W2026438690 @default.
• W3119431323 cites W2029966127 @default.
• W3119431323 cites W2030029573 @default.
• W3119431323 cites W2052567140 @default.
• W3119431323 cites W2063869821 @default.
• W3119431323 cites W2065853716 @default.
• W3119431323 cites W2067078308 @default.
• W3119431323 cites W2069474801 @default.
• W3119431323 cites W2071383434 @default.
• W3119431323 cites W2071599171 @default.
• W3119431323 cites W2079900290 @default.
• W3119431323 cites W2079909102 @default.
• W3119431323 cites W2085629163 @default.
• W3119431323 cites W2087057523 @default.
• W3119431323 cites W2087710066 @default.
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• W3119431323 cites W2138515605 @default.
• W3119431323 cites W2156864427 @default.
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• W3119431323 cites W2520867523 @default.
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• W3119431323 cites W2537986190 @default.
• W3119431323 cites W2610903424 @default.
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• W3119431323 cites W2747771949 @default.
• W3119431323 cites W2759933966 @default.
• W3119431323 cites W2767024564 @default.
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• W3119431323 doi "https://doi.org/10.2174/1573413716666201215165552" @default.
• W3119431323 hasPublicationYear "2021" @default.
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