FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119441180> ?p ?o ?g. }

• W3119441180 endingPage "3354" @default.
• W3119441180 startingPage "3333" @default.
• W3119441180 abstract "In recent years, cellular senescence has become the focus of attention in multiple areas of biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by increased cellular growth, metabolic activity and by a characteristic messaging secretome, cellular senescence can impact on multiple physiological and pathological processes such as wound healing, fibrosis, cancer and ageing. These unjustly called 'zombie cells' are indeed a rich source of opportunities for innovative therapeutic development. In this review, we collate the current understanding of the process of cellular senescence and its two-faced nature, i.e. beneficial/detrimental, and reason this duality is linked to contextual aspects. We propose the senescence programme as an endogenous pro-resolving mechanism that may lead to sustained inflammation and damage when dysregulated or when senescent cells are not cleared efficiently. This pro-resolving model reconciles the paradoxical two faces of senescence by emphasising that it is the unsuccessful completion of the programme, and not senescence itself, what leads to pathology. Thus, pro-senescence therapies under the right context, may favour inflammation resolution. We also review the evidence for the multiple therapeutic approaches under development based on senescence, including its induction, prevention, clearance and the use of senolytic and senomorphic drugs. In particular, we highlight the importance of the immune system in the favourable outcome of senescence and the implications of an inefficient immune surveillance in completion of the senescent cycle. Finally, we identify and discuss a number of challenges and existing gaps to encourage and stimulate further research in this exciting and unravelled field, with the hope of promoting and accelerating the clinical success of senescence-based therapies." @default.
• W3119441180 created "2021-01-18" @default.
• W3119441180 creator A5016097947 @default.
• W3119441180 creator A5062150857 @default.
• W3119441180 creator A5071268118 @default.
• W3119441180 creator A5078699232 @default.
• W3119441180 date "2021-01-13" @default.
• W3119441180 modified "2023-10-18" @default.
• W3119441180 title "Senescence under appraisal: hopes and challenges revisited" @default.
• W3119441180 cites W1033197108 @default.
• W3119441180 cites W1482964233 @default.
• W3119441180 cites W1553004656 @default.
• W3119441180 cites W1659141691 @default.
• W3119441180 cites W1856034726 @default.
• W3119441180 cites W1898081212 @default.
• W3119441180 cites W1910950086 @default.
• W3119441180 cites W1922866934 @default.
• W3119441180 cites W1932046626 @default.
• W3119441180 cites W1963578989 @default.
• W3119441180 cites W1970891016 @default.
• W3119441180 cites W1971049798 @default.
• W3119441180 cites W1976635482 @default.
• W3119441180 cites W1976881265 @default.
• W3119441180 cites W1977362098 @default.
• W3119441180 cites W1977800604 @default.
• W3119441180 cites W1980878904 @default.
• W3119441180 cites W1981687780 @default.
• W3119441180 cites W1982445841 @default.
• W3119441180 cites W1982481909 @default.
• W3119441180 cites W1983052307 @default.
• W3119441180 cites W1987142903 @default.
• W3119441180 cites W1993583543 @default.
• W3119441180 cites W1994369498 @default.
• W3119441180 cites W1996094302 @default.
• W3119441180 cites W1996846221 @default.
• W3119441180 cites W1999132652 @default.
• W3119441180 cites W2002034283 @default.
• W3119441180 cites W2004273407 @default.
• W3119441180 cites W2004314923 @default.
• W3119441180 cites W2005250235 @default.
• W3119441180 cites W2008144998 @default.
• W3119441180 cites W2013917575 @default.
• W3119441180 cites W2014418062 @default.
• W3119441180 cites W2016802652 @default.
• W3119441180 cites W2020090320 @default.
• W3119441180 cites W2023095530 @default.
• W3119441180 cites W2026384914 @default.
• W3119441180 cites W2027931017 @default.
• W3119441180 cites W2028169108 @default.
• W3119441180 cites W2030795773 @default.
• W3119441180 cites W2038024259 @default.
• W3119441180 cites W2042140414 @default.
• W3119441180 cites W2044341880 @default.
• W3119441180 cites W2045039711 @default.
• W3119441180 cites W2045264627 @default.
• W3119441180 cites W2048376025 @default.
• W3119441180 cites W2052388837 @default.
• W3119441180 cites W2054644399 @default.
• W3119441180 cites W2057204948 @default.
• W3119441180 cites W2057630805 @default.
• W3119441180 cites W2060814375 @default.
• W3119441180 cites W2061619522 @default.
• W3119441180 cites W2064377209 @default.
• W3119441180 cites W2069519394 @default.
• W3119441180 cites W2074871320 @default.
• W3119441180 cites W2076357723 @default.
• W3119441180 cites W2079241145 @default.
• W3119441180 cites W2079431297 @default.
• W3119441180 cites W2083594352 @default.
• W3119441180 cites W2084088993 @default.
• W3119441180 cites W2084289371 @default.
• W3119441180 cites W2087404852 @default.
• W3119441180 cites W2090067193 @default.
• W3119441180 cites W2095571230 @default.
• W3119441180 cites W2097606466 @default.
• W3119441180 cites W2099219058 @default.
• W3119441180 cites W2101960180 @default.
• W3119441180 cites W2103530035 @default.
• W3119441180 cites W2104397341 @default.
• W3119441180 cites W2104573359 @default.
• W3119441180 cites W2104908670 @default.
• W3119441180 cites W2108273756 @default.
• W3119441180 cites W2113044182 @default.
• W3119441180 cites W2115852450 @default.
• W3119441180 cites W2116054786 @default.
• W3119441180 cites W2120699390 @default.
• W3119441180 cites W2122297940 @default.
• W3119441180 cites W2123104757 @default.
• W3119441180 cites W2123799384 @default.
• W3119441180 cites W2124614845 @default.
• W3119441180 cites W2128864178 @default.
• W3119441180 cites W2130610927 @default.
• W3119441180 cites W2132224453 @default.
• W3119441180 cites W2134175163 @default.
• W3119441180 cites W2135564059 @default.
• W3119441180 cites W2138260513 @default.
• W3119441180 cites W2140930678 @default.
• W3119441180 cites W2147030667 @default.

• next