Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119457988> ?p ?o ?g. }
- W3119457988 endingPage "4582" @default.
- W3119457988 startingPage "4570" @default.
- W3119457988 abstract "Abstract Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and cGMP. They are members of a family of proteins that includes 11 subfamilies with different substrate specificities. Their main function is to catalyze the hydrolysis of cAMP, cGMP, or both. cAMP and cGMP are two key second messengers that modulate a wide array of intracellular processes and neurobehavioral functions, including memory and cognition. Even if these enzymes are present in all tissues, we focused on those PDEs that are expressed in the brain. We took into consideration genetic variants in patients affected by neurodevelopmental disorders, phenotypes of animal models, and pharmacological effects of PDE inhibitors, a class of drugs in rapid evolution and increasing application to brain disorders. Collectively, these data indicate the potential of PDE modulators to treat neurodevelopmental diseases characterized by learning and memory impairment, alteration of behaviors associated with depression, and deficits in social interaction. Indeed, clinical trials are in progress to treat patients with Alzheimer’s disease, schizophrenia, depression, and autism spectrum disorders. Among the most recent results, the application of some PDE inhibitors (PDE2A, PDE3, PDE4/4D, and PDE10A) to treat neurodevelopmental diseases, including autism spectrum disorders and intellectual disability, is a significant advance, since no specific therapies are available for these disorders that have a large prevalence. In addition, to highlight the role of several PDEs in normal and pathological neurodevelopment, we focused here on the deregulation of cAMP and/or cGMP in Down Syndrome, Fragile X Syndrome, Rett Syndrome, and intellectual disability associated with the CC2D1A gene." @default.
- W3119457988 created "2021-01-18" @default.
- W3119457988 creator A5013587879 @default.
- W3119457988 creator A5045096575 @default.
- W3119457988 date "2021-01-07" @default.
- W3119457988 modified "2023-10-14" @default.
- W3119457988 title "Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders" @default.
- W3119457988 cites W1515277465 @default.
- W3119457988 cites W1631029899 @default.
- W3119457988 cites W1751678494 @default.
- W3119457988 cites W1870545401 @default.
- W3119457988 cites W1877874306 @default.
- W3119457988 cites W190813598 @default.
- W3119457988 cites W1936340739 @default.
- W3119457988 cites W1959145352 @default.
- W3119457988 cites W1964849150 @default.
- W3119457988 cites W1966707642 @default.
- W3119457988 cites W1970002079 @default.
- W3119457988 cites W1973479286 @default.
- W3119457988 cites W1973617706 @default.
- W3119457988 cites W1975417204 @default.
- W3119457988 cites W1976344568 @default.
- W3119457988 cites W1976624715 @default.
- W3119457988 cites W1978701742 @default.
- W3119457988 cites W1979407816 @default.
- W3119457988 cites W1982985613 @default.
- W3119457988 cites W1987715420 @default.
- W3119457988 cites W1991311961 @default.
- W3119457988 cites W1992591110 @default.
- W3119457988 cites W1993135690 @default.
- W3119457988 cites W1997410784 @default.
- W3119457988 cites W2007124162 @default.
- W3119457988 cites W2014872693 @default.
- W3119457988 cites W2022991620 @default.
- W3119457988 cites W2023920385 @default.
- W3119457988 cites W2035000144 @default.
- W3119457988 cites W2039705542 @default.
- W3119457988 cites W2040900433 @default.
- W3119457988 cites W2044280569 @default.
- W3119457988 cites W2049268124 @default.
- W3119457988 cites W2053544091 @default.
- W3119457988 cites W2053719062 @default.
- W3119457988 cites W2064716701 @default.
- W3119457988 cites W2065090447 @default.
- W3119457988 cites W2067713216 @default.
- W3119457988 cites W2070069103 @default.
- W3119457988 cites W2074422008 @default.
- W3119457988 cites W2086712853 @default.
- W3119457988 cites W2087208986 @default.
- W3119457988 cites W2087938470 @default.
- W3119457988 cites W2087942365 @default.
- W3119457988 cites W2087972967 @default.
- W3119457988 cites W2094617144 @default.
- W3119457988 cites W2095126933 @default.
- W3119457988 cites W2095531349 @default.
- W3119457988 cites W2097688301 @default.
- W3119457988 cites W2103092595 @default.
- W3119457988 cites W2105051672 @default.
- W3119457988 cites W2105711200 @default.
- W3119457988 cites W2108328933 @default.
- W3119457988 cites W2108994842 @default.
- W3119457988 cites W2111057520 @default.
- W3119457988 cites W2118462346 @default.
- W3119457988 cites W2121155737 @default.
- W3119457988 cites W2127705828 @default.
- W3119457988 cites W2128858680 @default.
- W3119457988 cites W2130188089 @default.
- W3119457988 cites W2137187222 @default.
- W3119457988 cites W2138529679 @default.
- W3119457988 cites W2141888986 @default.
- W3119457988 cites W2142370148 @default.
- W3119457988 cites W2143070083 @default.
- W3119457988 cites W2143507642 @default.
- W3119457988 cites W2148969929 @default.
- W3119457988 cites W2153646973 @default.
- W3119457988 cites W2154558722 @default.
- W3119457988 cites W2158286182 @default.
- W3119457988 cites W2162169097 @default.
- W3119457988 cites W2169916014 @default.
- W3119457988 cites W2170532212 @default.
- W3119457988 cites W2267814186 @default.
- W3119457988 cites W2298567496 @default.
- W3119457988 cites W2388908044 @default.
- W3119457988 cites W2395003945 @default.
- W3119457988 cites W2413177566 @default.
- W3119457988 cites W2547995873 @default.
- W3119457988 cites W2557263742 @default.
- W3119457988 cites W2568391323 @default.
- W3119457988 cites W2584289628 @default.
- W3119457988 cites W2588751078 @default.
- W3119457988 cites W2590827917 @default.
- W3119457988 cites W2592150644 @default.
- W3119457988 cites W2593918913 @default.
- W3119457988 cites W2601277655 @default.
- W3119457988 cites W2613629789 @default.
- W3119457988 cites W2623056867 @default.
- W3119457988 cites W2647751342 @default.
- W3119457988 cites W2744464165 @default.