FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3119460081> ?p ?o ?g. }

• W3119460081 endingPage "51" @default.
• W3119460081 startingPage "39" @default.
• W3119460081 abstract "An increasing amount of evidence reveals that immunosuppression is a major issue in cancer progression. The association of immunoscore (IS) and its impact on clinical outcome have been studied in many tumor types, but its significance in intrahepatic cholangiocarcinoma (ICC) is poorly known.By immunohistochemistry, CD3 and CD8 expressions were assessed in tissue samples of 50 cases of postoperative ICC. The IS was determined by analyzing CD3+ and CD8+ expression data in different areas (intratumor and invasion margins). The relationship between IS and clinicopathological characteristics, including the overall survival (OS) and recurrence-free survival (RFS), was analyzed. In addition, PD-L1, a major regulator of immune escape, was also assessed in tumor cells by immunohistochemistry.IS was related to histological differentiation (P=0.026), the presence of lymphoid metastasis (P=0.034), and TNM clinical stages (P = 0.031) of ICC. High IS was significantly associated with better RFS (P=0.033) and OS (P=0.014). IS was an independent prognostic factor for better OS in multivariate analysis. PD-L1 expression was closely related to tumor vascular invasion (P=0.044). Although there was no association between PD-L1 expression and IS, high PD-L1 expression in tumor cells indicated poor RFS (P=0.017) and OS (P=0.004) in ICC.The IS and PD-L1 may be used as a complement to the TNM system for predicting the prognosis of patients with ICC." @default.
• W3119460081 created "2021-01-18" @default.
• W3119460081 creator A5004095831 @default.
• W3119460081 creator A5004797649 @default.
• W3119460081 creator A5044026422 @default.
• W3119460081 creator A5049866451 @default.
• W3119460081 creator A5066623694 @default.
• W3119460081 creator A5089653834 @default.
• W3119460081 creator A5090256693 @default.
• W3119460081 date "2021-01-01" @default.
• W3119460081 modified "2023-10-01" @default.
• W3119460081 title "Clinicopathological and Prognostic Significance of Immunoscore and PD-L1 in Intrahepatic Cholangiocarcinoma" @default.
• W3119460081 cites W1859257957 @default.
• W3119460081 cites W1868820697 @default.
• W3119460081 cites W1938027614 @default.
• W3119460081 cites W1949964307 @default.
• W3119460081 cites W2005501957 @default.
• W3119460081 cites W2011387799 @default.
• W3119460081 cites W2101585919 @default.
• W3119460081 cites W2122656254 @default.
• W3119460081 cites W2142300779 @default.
• W3119460081 cites W2294216513 @default.
• W3119460081 cites W2296767826 @default.
• W3119460081 cites W2376461033 @default.
• W3119460081 cites W2589651021 @default.
• W3119460081 cites W2624430276 @default.
• W3119460081 cites W2626512221 @default.
• W3119460081 cites W2746892915 @default.
• W3119460081 cites W2763492611 @default.
• W3119460081 cites W2784644666 @default.
• W3119460081 cites W2802343656 @default.
• W3119460081 cites W2893024156 @default.
• W3119460081 cites W2893903398 @default.
• W3119460081 cites W2898374497 @default.
• W3119460081 cites W2914163382 @default.
• W3119460081 cites W2940160729 @default.
• W3119460081 cites W2963941603 @default.
• W3119460081 cites W2967658120 @default.
• W3119460081 cites W2968650854 @default.
• W3119460081 cites W2971131263 @default.
• W3119460081 cites W2988644538 @default.
• W3119460081 cites W2990361149 @default.
• W3119460081 cites W3003062861 @default.
• W3119460081 cites W3005605254 @default.
• W3119460081 cites W3011184686 @default.
• W3119460081 cites W3039360174 @default.
• W3119460081 doi "https://doi.org/10.2147/ott.s288982" @default.
• W3119460081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7797318" @default.
• W3119460081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33442265" @default.
• W3119460081 hasPublicationYear "2021" @default.
• W3119460081 type Work @default.
• W3119460081 sameAs 3119460081 @default.
• W3119460081 citedByCount "8" @default.
• W3119460081 countsByYear W31194600812021 @default.
• W3119460081 countsByYear W31194600812022 @default.
• W3119460081 countsByYear W31194600812023 @default.
• W3119460081 crossrefType "journal-article" @default.
• W3119460081 hasAuthorship W3119460081A5004095831 @default.
• W3119460081 hasAuthorship W3119460081A5004797649 @default.
• W3119460081 hasAuthorship W3119460081A5044026422 @default.
• W3119460081 hasAuthorship W3119460081A5049866451 @default.
• W3119460081 hasAuthorship W3119460081A5066623694 @default.
• W3119460081 hasAuthorship W3119460081A5089653834 @default.
• W3119460081 hasAuthorship W3119460081A5090256693 @default.
• W3119460081 hasBestOaLocation W31194600811 @default.
• W3119460081 hasConcept C114684123 @default.
• W3119460081 hasConcept C121608353 @default.
• W3119460081 hasConcept C126322002 @default.
• W3119460081 hasConcept C142724271 @default.
• W3119460081 hasConcept C143998085 @default.
• W3119460081 hasConcept C167672396 @default.
• W3119460081 hasConcept C203014093 @default.
• W3119460081 hasConcept C204232928 @default.
• W3119460081 hasConcept C2777701055 @default.
• W3119460081 hasConcept C2779013556 @default.
• W3119460081 hasConcept C2780252810 @default.
• W3119460081 hasConcept C2781053074 @default.
• W3119460081 hasConcept C2909135397 @default.
• W3119460081 hasConcept C63363279 @default.
• W3119460081 hasConcept C71924100 @default.
• W3119460081 hasConcept C8891405 @default.
• W3119460081 hasConceptScore W3119460081C114684123 @default.
• W3119460081 hasConceptScore W3119460081C121608353 @default.
• W3119460081 hasConceptScore W3119460081C126322002 @default.
• W3119460081 hasConceptScore W3119460081C142724271 @default.
• W3119460081 hasConceptScore W3119460081C143998085 @default.
• W3119460081 hasConceptScore W3119460081C167672396 @default.
• W3119460081 hasConceptScore W3119460081C203014093 @default.
• W3119460081 hasConceptScore W3119460081C204232928 @default.
• W3119460081 hasConceptScore W3119460081C2777701055 @default.
• W3119460081 hasConceptScore W3119460081C2779013556 @default.
• W3119460081 hasConceptScore W3119460081C2780252810 @default.
• W3119460081 hasConceptScore W3119460081C2781053074 @default.
• W3119460081 hasConceptScore W3119460081C2909135397 @default.
• W3119460081 hasConceptScore W3119460081C63363279 @default.
• W3119460081 hasConceptScore W3119460081C71924100 @default.
• W3119460081 hasConceptScore W3119460081C8891405 @default.
• W3119460081 hasLocation W31194600811 @default.

• next