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• W3119461288 endingPage "115343" @default.
• W3119461288 startingPage "115343" @default.
• W3119461288 abstract "Aprepitant(APPT) is a drug used for suppressing nausea and vomiting. Here, an in-depth study was conducted on how the concentration of sodium salt electrolyte (NaCl or Na2SO4) and temperature (293.15–313.15 K with an interval of 5.0 K) affect the thermodynamics of APPT/HS15 micelle system in terms of the interface and micellization behavior. The critical micelle concentration (CMC) was evaluated from surface tension measurement. The results show that anions from the two electrolytes disrupted hydration of the surfactant and changed the CMC, dynamic light scattering, and the air-water interface parameters, thereby facilitating the formation of micelles. According to the measured standard Gibbs free energies for micellization and adsorption (∆Gm and ∆Gads, respectively), micellization between APPT and HS15 was spontaneous. The temperature and electrolyte have a synergistic effect on the spontaneous micellization. We also calculated related physical and chemical parameters such as the maximum surface excess concentration (Γmax), the molecular adsorption limit area (Amin), the effect on surface tension reduction (Πcmc), and the equilibrium surface free energy (∆Gmin). In the APPT/HS15 system, electrolytes lower the energy requirement for forming micelles and makes the formed micelles more stable. Above all, NaCl and Na2SO4 can stabilize the APPT/HS15 system, which provides a reference for the clinical application of APPT." @default.
• W3119461288 created "2021-01-18" @default.
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• W3119461288 date "2021-04-01" @default.
• W3119461288 modified "2023-10-18" @default.
• W3119461288 title "Physicochemical parameters and thermodynamic behavior of aprepitant/HS15 micellar system at different temperatures: Effect of electrolytes concentration" @default.
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• W3119461288 doi "https://doi.org/10.1016/j.molliq.2021.115343" @default.
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