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- W3119476912 abstract "Abastract Plasmonic nanomaterials, especially a wide variety of gold nanoparticles, demonstrate great potential for theranostics of cancer. Herein, a gold nanotriangle with CD133 and hyaluronic acid on its surface loaded with a near-infrared photosensitizer was prepared for enhanced photodynamic/photothermal combined anti-tumor therapy. CD133 and hyaluronic acid provide the nanoprobe with dual tumor targeting, while the hyaluronic acid also protects photosensitive drugs from photodegradation. Thus, the nanoprobe has enhanced photothermal/photodynamic effects. This integrated treatment strategy significantly enhanced photodynamic/photothermal destruction of osteosarcoma cells. In addition, this treatment, induced by mild irradiation with a single wavelength laser, inhibited tumor growth in an osteosarcoma mouse model. These results indicate that this systemic treatment strategy can achieve enhanced anti-tumor therapeutic effects through active tumor targeting and protection of the loaded drugs." @default.
- W3119476912 created "2021-01-18" @default.
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- W3119476912 date "2021-01-25" @default.
- W3119476912 modified "2023-10-10" @default.
- W3119476912 title "Gold nanoparticle-based nanoprobes with enhanced tumor targeting and photothermal/photodynamic response for therapy of osteosarcoma" @default.
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- W3119476912 doi "https://doi.org/10.1088/1361-6528/abd816" @default.
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